Immunogenetics in Stem Cell Donor Registry Work: The DKMS Example (Part 1)

Overview

Journal Int J Immunogenet

Specialties Allergy & Immunology
Genetics

Date 2020 Jan 7

PMID 31903698

Citations 19

Authors

Alexander H Schmidt

Jurgen Sauter

Daniel M Baier

Jessica Daiss

Andreas Keller

Anja Klussmeier

Thilo Mengling

Gabi Rall

Tobias Riethmuller

Gerhard Schofl

Ute V Solloch

Tigran Torosian

David Means

Helen Kelly

Latha Jagannathan

Patrick Paul

Anette S Giani

Sabine Hildebrand

Stephan Schumacher

Jan Markert

Monika Fussel

Jan A Hofmann

Thomas Schafer

Julia Pingel

Vinzenz Lange

Johannes Schetelig

Affiliations

Soon will be listed here.

Abstract

Currently, stem cell donor registries include more than 35 million potential donors worldwide to provide HLA-matched stem cell products for patients in need of an unrelated donor transplant. DKMS is a leading stem cell donor registry with more than 9 million donors from Germany, Poland, the United States, the United Kingdom, India and Chile. DKMS donors have donated hematopoietic stem cells more than 80,000 times. Many aspects of donor registry work are closely related to topics from immunogenetics or population genetics. In this two-part review article, we describe, analyse and discuss these areas of donor registry work by using the example of DKMS. Part 1 of the review gives a general overview on DKMS and includes typical donor registry activities with special focus on the HLA system: high-throughput HLA typing of potential stem cell donors, HLA haplotype frequencies and resulting matching probabilities, and donor file optimization with regard to HLA diversity.

Citing Articles

HLA allele and haplotype frequencies of eight Indian populations based on 130,518 registered stem cell donors.

Solloch U, Kaniyath Madhusoodhanan C, Lange V, Sauter J, Jagannathan L, Paul P Front Immunol. 2025; 16:1528177.

PMID: 40070842 PMC: 11893841. DOI: 10.3389/fimmu.2025.1528177.

Schmidt A Curr Opin Hematol. 2024; 31(6):251-260.

PMID: 39046928 PMC: 11426981. DOI: 10.1097/MOH.0000000000000835.

Racial/ethnic disparities in availability of volunteer unrelated donors for allogeneic transplantation.

Fingrut W, Davis E, Archer A, Brown S, Devlin S, Nhaissi M Blood Adv. 2024; 8(11):2753-2764.

PMID: 38429097 PMC: 11170144. DOI: 10.1182/bloodadvances.2023012385.

HLA haplotype frequencies and diversity in patients with hemoglobinopathies.

Scigliuolo G, Boukouaci W, Cappelli B, Volt F, Rivera Franco M, Dhedin N EJHaem. 2023; 4(4):963-969.

PMID: 38024588 PMC: 10660433. DOI: 10.1002/jha2.763.

5 years DKMS Chile: approach, results and impact of the first unrelated stem cell donor center in Chile.

Barriga F, Solloch U, Giani A, Palma J, Wietstruck A, Sarmiento M Front Med (Lausanne). 2023; 10:1236506.

PMID: 37901400 PMC: 10601464. DOI: 10.3389/fmed.2023.1236506.

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