Regional HLA Differences in Poland and Their Effect on Stem Cell Donor Registry Planning

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2013 Sep 27

PMID 24069237

Citations 7

Authors

Alexander H Schmidt

Ute V Solloch

Julia Pingel

Jurgen Sauter

Irina Bohme

Nezih Cereb

Kinga Dubicka

Stephan Schumacher

Jacek Wachowiak

Gerhard Ehninger

Affiliations

Soon will be listed here.

Abstract

Regional HLA frequency differences are of potential relevance for the optimization of stem cell donor recruitment. We analyzed a very large sample (n = 123,749) of registered Polish stem cell donors. Donor figures by 1-digit postal code regions ranged from n = 5,243 (region 9) to n = 19,661 (region 8). Simulations based on region-specific haplotype frequencies showed that donor recruitment in regions 0, 2, 3 and 4 (mainly located in the south-eastern part of Poland) resulted in an above-average increase of matching probabilities for Polish patients. Regions 1, 7, 8, 9 (mainly located in the northern part of Poland) showed an opposite behavior. However, HLA frequency differences between regions were generally small. A strong indication for regionally focused donor recruitment efforts can, therefore, not be derived from our analyses. Results of haplotype frequency estimations showed sample size effects even for sizes between n≈5,000 and n≈20,000. This observation deserves further attention as most published haplotype frequency estimations are based on much smaller samples.

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