Estimating HLA Haplotype Frequencies from Homozygous Individuals - A Technical Report

Overview

Journal Int J Immunogenet

Specialties Allergy & Immunology
Genetics

Date 2021 Sep 27

PMID 34570965

Citations 6

Authors

Susanne Seitz

Vinzenz Lange

Paul J Norman

Jurgen Sauter

Alexander H Schmidt

Affiliations

Soon will be listed here.

Abstract

We estimated HLA haplotype frequencies based on individuals homozygous for 4, 5 or 6 loci. Validation of our approach using a sample of over 3.4 million German individuals was successful. Compared to an expectation-maximization algorithm, the errors were larger. However, our approach allows the unequivocal detection of rare haplotypes.

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