Identification of an Interleukin (IL)-25-dependent Cell Population That Provides IL-4, IL-5, and IL-13 at the Onset of Helminth Expulsion

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 2006 Apr 12

PMID 16606668

Citations 379

Authors

Padraic G Fallon

Sarah J Ballantyne

Niamh E Mangan

Jillian L Barlow

Ayan Dasvarma

Duncan R Hewett

Ann McIlgorm

Helen E Jolin

Andrew N J McKenzie

Affiliations

Soon will be listed here.

Abstract

Type 2 immunity, which involves coordinated regulation of innate and adaptive immune responses, can protect against helminth parasite infection, but may lead to allergy and asthma after inappropriate activation. We demonstrate that il25(-/-) mice display inefficient Nippostrongylus brasiliensis expulsion and delayed cytokine production by T helper 2 cells. We further establish a key role for interleukin (IL)-25 in regulating a novel population of IL-4-, IL-5-, IL-13-producing non-B/non-T (NBNT), c-kit+, FcepsilonR1- cells during helminth infection. A deficit in this population in il25(-/-) mice correlates with inefficient N. brasiliensis expulsion. In contrast, administration of recombinant IL-25 in vivo induces the appearance of NBNT, c-kit+, FcepsilonR1- cells and leads to rapid worm expulsion that is T and B cell independent, but type 2 cytokine dependent. We demonstrate that these IL-25-regulated cells appear rapidly in the draining lymph nodes, implicating them as a source of type 2 cytokines during initiation of worm expulsion.

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