Andrew J Martins
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Explore the profile of Andrew J Martins including associated specialties, affiliations and a list of published articles.
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33
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1052
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Recent Articles
1.
Bosticardo M, Dobbs K, Delmonte O, Martins A, Pala F, Kawai T, et al.
Sci Immunol
. 2025 Jan;
10(103):eadq1697.
PMID: 39792639
Human recombination-activating gene (RAG) deficiency can manifest with distinct clinical and immunological phenotypes. By applying a multiomics approach to a large group of -mutated patients, we aimed at characterizing the...
2.
Diaz-Perez S, DeLong J, Rivier C, Lee C, Askenase M, Zhu B, et al.
bioRxiv
. 2024 Dec;
PMID: 39713290
Vascular dementia (VaD) refers to a variety of dementias driven by cerebrovascular disease and is the second leading cause of dementia globally. VaD may be caused by ischemic strokes, intracerebral...
3.
Apps R, Biancotto A, Candia J, Kotliarov Y, Perl S, Cheung F, et al.
Cell Rep
. 2024 Sep;
43(9):114706.
PMID: 39235945
To gain insight into how an adjuvant impacts vaccination responses, we use systems immunology to study human H5N1 influenza vaccination with or without the adjuvant AS03, longitudinally assessing 14 time...
4.
Lledo-Delgado A, Preston-Hurlburt P, Currie S, Clark P, Linsley P, Long S, et al.
J Clin Invest
. 2024 Aug;
134(18).
PMID: 39137044
BACKGROUNDTeplizumab, a non-FcR-binding anti-CD3 mAb, is approved to delay progression of type 1 diabetes (T1D) in at-risk patients. Previous investigations described the immediate effects of the 14-day treatment, but longer-term...
5.
Sparks R, Rachmaninoff N, Lau W, Hirsch D, Bansal N, Martins A, et al.
Nat Med
. 2024 Jul;
30(9):2461-2472.
PMID: 38961223
Immunological health has been challenging to characterize but could be defined as the absence of immune pathology. While shared features of some immune diseases and the concept of immunologic resilience...
6.
Mule M, Martins A, Cheung F, Farmer R, Sellers B, Quiel J, et al.
Immunity
. 2024 May;
57(5):1160-1176.e7.
PMID: 38697118
Multimodal single-cell profiling methods can capture immune cell variations unfolding over time at the molecular, cellular, and population levels. Transforming these data into biological insights remains challenging. Here, we introduce...
7.
Mura M, Misganaw B, Gautam A, Robinson T, Chaudhury S, Bansal N, et al.
Hum Vaccin Immunother
. 2023 Nov;
19(3):2282693.
PMID: 38010150
The identification of immune correlates of protection against infectious pathogens will accelerate the design and optimization of recombinant and subunit vaccines. Systematic analyses such as immunoprofiling including serological, cellular, and...
8.
de Assis F, Hoehn K, Zhang X, Kardava L, Smith C, El Merhebi O, et al.
Cell Rep
. 2023 Jul;
42(7):112780.
PMID: 37440409
Protective immunity following vaccination is sustained by long-lived antibody-secreting cells and resting memory B cells (MBCs). Responses to two-dose SARS-CoV-2 mRNA-1273 vaccination are evaluated longitudinally by multimodal single-cell analysis in...
9.
Mule M, Martins A, Cheung F, Farmer R, Sellers B, Quiel J, et al.
medRxiv
. 2023 Apr;
PMID: 37090674
Advances in multimodal single cell analysis can empower high-resolution dissection of human vaccination responses. The resulting data capture multiple layers of biological variations, including molecular and cellular states, vaccine formulations,...
10.
Sparks R, Rachmaninoff N, Hirsch D, Bansal N, Lau W, Martins A, et al.
Res Sq
. 2023 Mar;
PMID: 36993430
Monogenic diseases are often studied in isolation due to their rarity. Here we utilize multiomics to assess 22 monogenic immune-mediated conditions with age- and sex-matched healthy controls. Despite clearly detectable...