T Cell Factor 1 is Required for Group 2 Innate Lymphoid Cell Generation

Overview

Journal Immunity

Publisher Cell Press

Specialty Allergy & Immunology

Date 2013 Apr 23

PMID 23601684

Citations 140

Authors

Qi Yang

Laurel A Monticelli

Steven A Saenz

Anthony Wei-Shine Chi

Gregory F Sonnenberg

Jiangbo Tang

Maria Elena De Obaldia

Will Bailis

Jerrod L Bryson

Kristin Toscano

Jian Huang

Angela Haczku

Warren S Pear

David Artis

Avinash Bhandoola

Affiliations

Soon will be listed here.

Abstract

Group 2 innate lymphoid cells (ILC2) are innate lymphocytes that confer protective type 2 immunity during helminth infection and are also involved in allergic airway inflammation. Here we report that ILC2 development required T cell factor 1 (TCF-1, the product of the Tcf7 gene), a transcription factor also implicated in T cell lineage specification. Tcf7(-/-) mice lack ILC2, and were unable to mount ILC2-mediated innate type 2 immune responses. Forced expression of TCF-1 in bone marrow progenitors partially bypassed the requirement for Notch signaling in the generation of ILC2 in vivo. TCF-1 acted through both GATA-3-dependent and GATA-3-independent pathways to promote the generation of ILC2. These results are reminiscent of the critical roles of TCF-1 in early T cell development. Hence, transcription factors that underlie early steps of T cell development are also implicated in the development of innate lymphoid cells.

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