Emergence of Carbapenem-Resistant Producing NDM-1 and VIM-2 Metallo-β-Lactamases in Myanmar

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 2019 May 30

PMID 31138570

Citations 12

Authors

Mari Tohya

Tatsuya Tada

Shin Watanabe

Kyoko Kuwahara-Arai

Khwar Nyo Zin

Ni Ni Zaw

May Yee Aung

San Mya

Khin Nyein Zan

Teruo Kirikae

Htay Htay Tin

Affiliations

Soon will be listed here.

Abstract

is a recently proposed species of the genus This study describes eight isolates of carbapenem-resistant harboring and , genes encoding metallo-β-lactamase (MBL). These isolates were obtained from urine samples of patients hospitalized in Myanmar. These isolates were resistant to carbapenems but susceptible to colistin. All eight isolates were positive for a carbapenemase inactivation method, CIMTrisII, and seven were positive on an immunochromatographic assay for NDM-type MBL. One isolate was highly resistant to aminoglycosides. Whole-genome sequencing showed that seven isolates harbored and one harbored , with these genes located on the chromosome. One isolate harbored and , a gene encoding 16S rRNA methylase. Five types of genomic environments surrounding and were detected in these eight isolates, with four isolates having the same type. These data indicate that isolates harboring genes encoding carbapenemases, including and , are spreading in medical settings in Myanmar.

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