Isolation of VIM-2-producing Pseudomonas Monteilii Clinical Strains Disseminated in a Tertiary Hospital in Northern Spain

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 2014 Nov 26

PMID 25421471

Citations 11

Authors

Alain A Ocampo-Sosa

Laura P Guzman-Gomez

Marta Fernandez-Martinez

Elena Roman

Cristina Rodriguez

Francesc Marco

Jordi Vila

Luis Martinez-Martinez

Affiliations

Soon will be listed here.

Abstract

We describe here the occurrence of blaVIM-2 in 10 carbapenem-resistant Pseudomonas monteilii strains isolated from different clinical samples from patients at the University Hospital Marqués de Valdecilla in northern Spain. All the blaVIM-2-harboring P. monteilii isolates possessed a class 1 integron, with the cassette array [intI1_blaVIM-2_aac(6')-Ib_qacEΔ1_sul1]. Our results show the emergence of VIM-2-producing multidrug-resistant species other than Pseudomonas aeruginosa or Pseudomonas putida in a Spanish hospital. P. monteilii, although sporadically isolated, should also be considered an important metallo-β-lactamase (MBL) reservoir.

Citing Articles

The CARBA-MAP study: national mapping of carbapenemases in Spain (2014-2018).

Gracia-Ahufinger I, Lopez-Gonzalez L, Vasallo F, Galar A, Siller M, Pitart C Front Microbiol. 2023; 14:1247804.

PMID: 37744921 PMC: 10516297. DOI: 10.3389/fmicb.2023.1247804.

Genomic Epidemiology of MBL-Producing Pseudomonas putida Group Isolates in Poland.

Urbanowicz P, Izdebski R, Biedrzycka M, Literacka E, Hryniewicz W, Gniadkowski M Infect Dis Ther. 2022; 11(4):1725-1740.

PMID: 35689153 PMC: 9334476. DOI: 10.1007/s40121-022-00659-z.

VIM-encoding Inc plasmids and chromosome-borne integrative and mobilizable elements (IMEs) and integrative and conjugative elements (ICEs) in Pseudomonas.

Chen F, Wang P, Yin Z, Yang H, Hu L, Yu T Ann Clin Microbiol Antimicrob. 2022; 21(1):10.

PMID: 35264204 PMC: 8905914. DOI: 10.1186/s12941-022-00502-w.

Comprehensive Genomic Survey of Antimicrobial-Resistance Bacteria in the Sewage Tank Replacement with Hospital Relocation.

Katagiri M, Kuroda M, Sekizuka T, Nakada N, Ito Y, Otsuka M Infect Drug Resist. 2022; 14:5563-5574.

PMID: 34984011 PMC: 8709547. DOI: 10.2147/IDR.S336418.

Carbapenem Resistance among Marine Bacteria-An Emerging Threat to the Global Health Sector.

Dewi D, Thomas T, Mokhtar A, Mat Nanyan N, Zulfigar S, Salikin N Microorganisms. 2021; 9(10).

PMID: 34683467 PMC: 8537846. DOI: 10.3390/microorganisms9102147.

References

Romling U, Tummler B . Achieving 100% typeability of Pseudomonas aeruginosa by pulsed-field gel electrophoresis. J Clin Microbiol. 2000; 38(1):464-5. PMC: 88754. DOI: 10.1128/JCM.38.1.464-465.2000. View

Miro E, Grunbaum F, Gomez L, Rivera A, Mirelis B, Coll P . Characterization of aminoglycoside-modifying enzymes in enterobacteriaceae clinical strains and characterization of the plasmids implicated in their diffusion. Microb Drug Resist. 2012; 19(2):94-9. DOI: 10.1089/mdr.2012.0125. View

Docquier J, Lamotte-Brasseur J, Galleni M, Amicosante G, Frere J, Rossolini G . On functional and structural heterogeneity of VIM-type metallo-beta-lactamases. J Antimicrob Chemother. 2003; 51(2):257-66. DOI: 10.1093/jac/dkg067. View

Elomari M, Coroler L, Verhille S, Izard D, Leclerc H . Pseudomonas monteilii sp. nov., isolated from clinical specimens. Int J Syst Bacteriol. 1997; 47(3):846-52. DOI: 10.1099/00207713-47-3-846. View

Walsh T, Toleman M, Poirel L, Nordmann P . Metallo-beta-lactamases: the quiet before the storm?. Clin Microbiol Rev. 2005; 18(2):306-25. PMC: 1082798. DOI: 10.1128/CMR.18.2.306-325.2005. View

Carattoli A, Bertini A, Villa L, Falbo V, Hopkins K, Threlfall E . Identification of plasmids by PCR-based replicon typing. J Microbiol Methods. 2005; 63(3):219-28. DOI: 10.1016/j.mimet.2005.03.018. View

Park C, Robicsek A, Jacoby G, Sahm D, Hooper D . Prevalence in the United States of aac(6')-Ib-cr encoding a ciprofloxacin-modifying enzyme. Antimicrob Agents Chemother. 2006; 50(11):3953-5. PMC: 1635235. DOI: 10.1128/AAC.00915-06. View

Gutierrez O, Juan C, Cercenado E, Navarro F, Bouza E, Coll P . Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa isolates from Spanish hospitals. Antimicrob Agents Chemother. 2007; 51(12):4329-35. PMC: 2167976. DOI: 10.1128/AAC.00810-07. View

Dubois V, Arpin C, Dupart V, Scavelli A, Coulange L, Andre C . Beta-lactam and aminoglycoside resistance rates and mechanisms among Pseudomonas aeruginosa in French general practice (community and private healthcare centres). J Antimicrob Chemother. 2008; 62(2):316-23. DOI: 10.1093/jac/dkn174. View

10.

Nicolau C, Oliver A . [Carbapenemases in Pseudomonas spp]. Enferm Infecc Microbiol Clin. 2010; 28 Suppl 1:19-28. DOI: 10.1016/S0213-005X(10)70004-5. View

11.

Mulet M, Lalucat J, Garcia-Valdes E . DNA sequence-based analysis of the Pseudomonas species. Environ Microbiol. 2010; 12(6):1513-30. DOI: 10.1111/j.1462-2920.2010.02181.x. View

12.

Walsh T . Emerging carbapenemases: a global perspective. Int J Antimicrob Agents. 2010; 36 Suppl 3:S8-14. DOI: 10.1016/S0924-8579(10)70004-2. View

13.

Cornaglia G, Giamarellou H, Rossolini G . Metallo-β-lactamases: a last frontier for β-lactams?. Lancet Infect Dis. 2011; 11(5):381-93. DOI: 10.1016/S1473-3099(11)70056-1. View

14.

Bogaerts P, Bouchahrouf W, Lissoir B, Denis O, Glupczynski Y . IMP-13-producing Pseudomonas monteilii recovered in a hospital environment. J Antimicrob Chemother. 2011; 66(10):2434-5. DOI: 10.1093/jac/dkr294. View

15.

Scotta C, Juan C, Cabot G, Oliver A, Lalucat J, Bennasar A . Environmental microbiota represents a natural reservoir for dissemination of clinically relevant metallo-beta-lactamases. Antimicrob Agents Chemother. 2011; 55(11):5376-9. PMC: 3195059. DOI: 10.1128/AAC.00716-11. View

16.

Ruiz E, Ocampo-Sosa A, Alcoba-Florez J, Roman E, Arlet G, Torres C . Changes in ciprofloxacin resistance levels in Enterobacter aerogenes isolates associated with variable expression of the aac(6')-Ib-cr gene. Antimicrob Agents Chemother. 2011; 56(2):1097-100. PMC: 3264215. DOI: 10.1128/AAC.05074-11. View

17.

Leiros H, Borra P, Brandsdal B, Edvardsen K, Spencer J, Walsh T . Crystal structure of the mobile metallo-β-lactamase AIM-1 from Pseudomonas aeruginosa: insights into antibiotic binding and the role of Gln157. Antimicrob Agents Chemother. 2012; 56(8):4341-53. PMC: 3421596. DOI: 10.1128/AAC.00448-12. View

18.

Ma Q, Qu Y, Tang H, Yu H, Ma F, Shi S . Genome sequence of a novel indigo-producing strain, Pseudomonas monteilii QM. J Bacteriol. 2012; 194(16):4459-60. PMC: 3416222. DOI: 10.1128/JB.00867-12. View

19.

Yong D, Toleman M, Bell J, Ritchie B, Pratt R, Ryley H . Genetic and biochemical characterization of an acquired subgroup B3 metallo-β-lactamase gene, blaAIM-1, and its unique genetic context in Pseudomonas aeruginosa from Australia. Antimicrob Agents Chemother. 2012; 56(12):6154-9. PMC: 3497169. DOI: 10.1128/AAC.05654-11. View

20.

Pollini S, Maradei S, Pecile P, Olivo G, Luzzaro F, Docquier J . FIM-1, a new acquired metallo-β-lactamase from a Pseudomonas aeruginosa clinical isolate from Italy. Antimicrob Agents Chemother. 2012; 57(1):410-6. PMC: 3535987. DOI: 10.1128/AAC.01953-12. View