Circular RNAs As Potential Biomarkers and Therapeutics for Cardiovascular Disease

Overview

Journal PeerJ

Specialties Biology
Environmental Health
General Medicine

Date 2019 May 24

PMID 31119072

Citations 26

Authors

Weitie Wang

Yong Wang

Hulin Piao

Bo Li

MaoXun Huang

Zhicheng Zhu

Dan Li

Tiance Wang

Rihao Xu

Kexiang Liu

Affiliations

Soon will be listed here.

Abstract

Circular RNAs (circRNAs) are genetic regulators that were earlier considered as "junk". In contrast to linear RNAs, they have covalently linked ends with no polyadenylated tails. CircRNAs can act as RNA-binding proteins, sequestering agents, transcriptional regulators, as well as microRNA sponges. In addition, it is reported that some selected circRNAs are transformed into functional proteins. These RNA molecules always circularize through covalent bonds, and their presence has been demonstrated across species. They are usually abundant and stable as well as evolutionarily conserved in tissues (liver, lung, stomach), saliva, exosomes, and blood. Therefore, they have been proposed as the "next big thing" in molecular biomarkers for several diseases, particularly in cancer. Recently, circRNAs have been investigated in cardiovascular diseases (CVD) and reported to play important roles in heart failure, coronary artery disease, and myocardial infarction. Here, we review the recent literature and discuss the impact and the diagnostic and prognostic values of circRNAs in CVD.

Citing Articles

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