Targeting Epigenetics and Non-coding RNAs in Myocardial Infarction: From Mechanisms to Therapeutics

Overview

Journal Front Genet

Date 2022 Jan 6

PMID 34987550

Citations 4

Authors

Jinhong Chen

Zhichao Liu

Li Ma

Shengwei Gao

Huanjie Fu

Can Wang

Anmin Lu

Baohe Wang

Xufang Gu

Affiliations

Soon will be listed here.

Abstract

Myocardial infarction (MI) is a complicated pathology triggered by numerous environmental and genetic factors. Understanding the effect of epigenetic regulation mechanisms on the cardiovascular disease would advance the field and promote prophylactic methods targeting epigenetic mechanisms. Genetic screening guides individualised MI therapies and surveillance. The present review reported the latest development on the epigenetic regulation of MI in terms of DNA methylation, histone modifications, and microRNA-dependent MI mechanisms and the novel therapies based on epigenetics.

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