Elucidation of Epigenetic Landscape in Coronary Artery Disease: A Review on Basic Concept to Personalized Medicine

Overview

Journal Epigenet Insights

Date 2021 Feb 18

PMID 33598635

Citations 8

Authors

Mamta P Sumi

Bhawna Mahajan

Real Sumayya Abdul Sattar

Nimisha

Apurva

Arun Kumar

Abhay Kumar Sharma

Ejaz Ahmad

Asgar Ali

Sundeep Singh Saluja

Affiliations

Soon will be listed here.

Abstract

Despite extensive clinical research and management protocols applied in the field of coronary artery diseases (CAD), it still holds the number 1 position in mortality worldwide. This indicates that we need to work on precision medicine to discover the diagnostic, therapeutic, and prognostic targets to improve the outcome of CAD. In precision medicine, epigenetic changes play a vital role in disease onset and progression. Epigenetics is the study of heritable changes that do not affect the alterations of DNA sequence in the genome. It comprises various covalent modifications that occur in DNA or histone proteins affecting the spatial arrangement of the DNA and histones. These multiple modifications include DNA/histone methylation, acetylation, phosphorylation, and SUMOylation. Besides these covalent modifications, non-coding RNAs-viz. miRNA, lncRNA, and circRNA are also involved in epigenetics. Smoking, alcohol, diet, environmental pollutants, obesity, and lifestyle are some of the prime factors affecting epigenetic alterations. Novel molecular techniques such as next-generation sequencing, chromatin immunoprecipitation, and mass spectrometry have been developed to identify important cross points in the epigenetic web in relation to various diseases. The studies regarding exploration of epigenetics, have led researchers to identify multiple diagnostic markers and therapeutic targets that are being used in different disease diagnosis and management. Here in this review, we will discuss various ground-breaking contributions of past and recent studies in the epigenetic field in concert with coronary artery diseases. Future prospects of epigenetics and its implication in CAD personalized medicine will also be discussed in brief.

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References

Alegria-Torres J, Baccarelli A, Bollati V . Epigenetics and lifestyle. Epigenomics. 2011; 3(3):267-77. PMC: 3752894. DOI: 10.2217/epi.11.22. View

Cheng Y, Tan N, Yang J, Liu X, Cao X, He P . A translational study of circulating cell-free microRNA-1 in acute myocardial infarction. Clin Sci (Lond). 2010; 119(2):87-95. PMC: 3593815. DOI: 10.1042/CS20090645. View

Lee E, Elhassan S, Ling Lim G, Kok W, Tan S, Leong E . The roles of circular RNAs in human development and diseases. Biomed Pharmacother. 2018; 111:198-208. DOI: 10.1016/j.biopha.2018.12.052. View

Wolf S . The protein arginine methyltransferase family: an update about function, new perspectives and the physiological role in humans. Cell Mol Life Sci. 2009; 66(13):2109-21. PMC: 11115746. DOI: 10.1007/s00018-009-0010-x. View

Dhingra R, Vasan R . Age as a risk factor. Med Clin North Am. 2012; 96(1):87-91. PMC: 3297980. DOI: 10.1016/j.mcna.2011.11.003. View

Hangauer M, Vaughn I, McManus M . Pervasive transcription of the human genome produces thousands of previously unidentified long intergenic noncoding RNAs. PLoS Genet. 2013; 9(6):e1003569. PMC: 3688513. DOI: 10.1371/journal.pgen.1003569. View

Smith Z, Chan M, Mikkelsen T, Gu H, Gnirke A, Regev A . A unique regulatory phase of DNA methylation in the early mammalian embryo. Nature. 2012; 484(7394):339-44. PMC: 3331945. DOI: 10.1038/nature10960. View

Zhu S, Goldschmidt-Clermont P, Dong C . Inactivation of monocarboxylate transporter MCT3 by DNA methylation in atherosclerosis. Circulation. 2005; 112(9):1353-61. DOI: 10.1161/CIRCULATIONAHA.104.519025. View

Banerjee S, Ponde C, Rajani R, Ashavaid T . Differential methylation pattern in patients with coronary artery disease: pilot study. Mol Biol Rep. 2018; 46(1):541-550. DOI: 10.1007/s11033-018-4507-y. View

10.

Mirsky A, RIS H . The desoxyribonucleic acid content of animal cells and its evolutionary significance. J Gen Physiol. 1951; 34(4):451-62. PMC: 2147229. DOI: 10.1085/jgp.34.4.451. View

11.

Cheung W, Briggs S, Allis C . Acetylation and chromosomal functions. Curr Opin Cell Biol. 2000; 12(3):326-33. DOI: 10.1016/s0955-0674(00)00096-x. View

12.

Roth G, Johnson C, Abajobir A, Abd-Allah F, Abera S, Abyu G . Global, Regional, and National Burden of Cardiovascular Diseases for 10 Causes, 1990 to 2015. J Am Coll Cardiol. 2017; 70(1):1-25. PMC: 5491406. DOI: 10.1016/j.jacc.2017.04.052. View

13.

Wang H, Liu Y, Zhong J, Wu C, Zhong Y, Yang G . Long noncoding RNA ANRIL as a novel biomarker of lymph node metastasis and prognosis in human cancer: a meta-analysis. Oncotarget. 2018; 9(18):14608-14618. PMC: 5865693. DOI: 10.18632/oncotarget.21825. View

14.

Hiltunen M, Turunen M, Hakkinen T, Rutanen J, Hedman M, Makinen K . DNA hypomethylation and methyltransferase expression in atherosclerotic lesions. Vasc Med. 2002; 7(1):5-11. DOI: 10.1191/1358863x02vm418oa. View

15.

Abi Khalil C . The emerging role of epigenetics in cardiovascular disease. Ther Adv Chronic Dis. 2014; 5(4):178-87. PMC: 4049125. DOI: 10.1177/2040622314529325. View

16.

Tsukada Y, Fang J, Erdjument-Bromage H, Warren M, Borchers C, Tempst P . Histone demethylation by a family of JmjC domain-containing proteins. Nature. 2005; 439(7078):811-6. DOI: 10.1038/nature04433. View

17.

Maas A, Appelman Y . Gender differences in coronary heart disease. Neth Heart J. 2011; 18(12):598-602. PMC: 3018605. DOI: 10.1007/s12471-010-0841-y. View

18.

Ono K, Kuwabara Y, Horie T, Kimura T . Long Non-Coding RNAs as Key Regulators of Cardiovascular Diseases. Circ J. 2018; 82(5):1231-1236. DOI: 10.1253/circj.CJ-18-0169. View

19.

Baccarelli A, Wright R, Bollati V, Litonjua A, Zanobetti A, Tarantini L . Ischemic heart disease and stroke in relation to blood DNA methylation. Epidemiology. 2010; 21(6):819-28. PMC: 3690659. DOI: 10.1097/EDE.0b013e3181f20457. View

20.

Valencia-Morales M, Zaina S, Heyn H, Javier Carmona F, Varol N, Sayols S . The DNA methylation drift of the atherosclerotic aorta increases with lesion progression. BMC Med Genomics. 2015; 8:7. PMC: 4353677. DOI: 10.1186/s12920-015-0085-1. View