Circular RNAs: Splicing's Enigma Variations

Overview

Journal EMBO J

Specialties Biotechnology
Molecular Biology

Date 2013 Mar 7

PMID 23463100

Citations 271

Authors

Matthias W Hentze

Thomas Preiss

Affiliations

Soon will be listed here.

Citing Articles

Identifying insulin-responsive circRNAs in chicken pectoralis.

Shao B, Wang Z, Luo P, Du P, Zhang X, Zhang H BMC Genomics. 2025; 26(1):148.

PMID: 39955508 PMC: 11830218. DOI: 10.1186/s12864-025-11347-w.

Liquid biopsy in cancer current: status, challenges and future prospects.

Ma L, Guo H, Zhao Y, Liu Z, Wang C, Bu J Signal Transduct Target Ther. 2024; 9(1):336.

PMID: 39617822 PMC: 11609310. DOI: 10.1038/s41392-024-02021-w.

Investigating the biomarker value of circRNAs in the diagnosis of colorectal cancer: a systematic review.

Latifi-Pakdehi T, Khezrian A, Doosti-Irani A, Afshar S, Mahdavinezhad A Discov Oncol. 2024; 15(1):734.

PMID: 39616555 PMC: 11609141. DOI: 10.1007/s12672-024-01602-z.

Conditional Knockdown of Endogenous MicroRNAs in CHO Cells Using TET-ON-SanDI Sponge Vectors.

Costello A, Lao N, Clynes M, Barron N Methods Mol Biol. 2024; 2853:71-84.

PMID: 39460915 DOI: 10.1007/978-1-0716-4104-0_6.

Molecular significance of circRNAs in malignant lymphoproliferative disorders: pathogenesis and novel biomarkers or therapeutic targets.

Long B, Wang Y, Hao S, Shi G Am J Cancer Res. 2024; 14(9):4633-4651.

PMID: 39417189 PMC: 11477815. DOI: 10.62347/KMWB5164.

References

Chen C, Sarnow P . Initiation of protein synthesis by the eukaryotic translational apparatus on circular RNAs. Science. 1995; 268(5209):415-7. DOI: 10.1126/science.7536344. View

Salzman J, Gawad C, Wang P, Lacayo N, Brown P . Circular RNAs are the predominant transcript isoform from hundreds of human genes in diverse cell types. PLoS One. 2012; 7(2):e30733. PMC: 3270023. DOI: 10.1371/journal.pone.0030733. View

Wu Q, Wang Y, Cao M, Pantaleo V, Burgyan J, Li W . Homology-independent discovery of replicating pathogenic circular RNAs by deep sequencing and a new computational algorithm. Proc Natl Acad Sci U S A. 2012; 109(10):3938-43. PMC: 3309787. DOI: 10.1073/pnas.1117815109. View

Ebert M, Sharp P . Emerging roles for natural microRNA sponges. Curr Biol. 2010; 20(19):R858-61. PMC: 4070712. DOI: 10.1016/j.cub.2010.08.052. View

Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A . Circular RNAs are a large class of animal RNAs with regulatory potency. Nature. 2013; 495(7441):333-8. DOI: 10.1038/nature11928. View

Hansen T, Wiklund E, Bramsen J, Villadsen S, Statham A, Clark S . miRNA-dependent gene silencing involving Ago2-mediated cleavage of a circular antisense RNA. EMBO J. 2011; 30(21):4414-22. PMC: 3230379. DOI: 10.1038/emboj.2011.359. View

Jeck W, Sorrentino J, Wang K, Slevin M, Burd C, Liu J . Circular RNAs are abundant, conserved, and associated with ALU repeats. RNA. 2012; 19(2):141-57. PMC: 3543092. DOI: 10.1261/rna.035667.112. View

Hansen T, Jensen T, Clausen B, Bramsen J, Finsen B, Damgaard C . Natural RNA circles function as efficient microRNA sponges. Nature. 2013; 495(7441):384-8. DOI: 10.1038/nature11993. View

Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann B, Strein C . Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell. 2012; 149(6):1393-406. DOI: 10.1016/j.cell.2012.04.031. View

10.

Capel B, Swain A, Nicolis S, Hacker A, Walter M, Koopman P . Circular transcripts of the testis-determining gene Sry in adult mouse testis. Cell. 1993; 73(5):1019-30. DOI: 10.1016/0092-8674(93)90279-y. View

11.

Mercer T, Gerhardt D, Dinger M, Crawford J, Trapnell C, Jeddeloh J . Targeted RNA sequencing reveals the deep complexity of the human transcriptome. Nat Biotechnol. 2011; 30(1):99-104. PMC: 3710462. DOI: 10.1038/nbt.2024. View