Molecular Mechanisms of Long Noncoding RNAs-mediated Cancer Metastasis

Overview

Journal Genes Chromosomes Cancer

Specialties Molecular Biology
Oncology

Date 2018 Oct 24

PMID 30350428

Citations 57

Authors

Yajuan Li

Sergey D Egranov

Liuqing Yang

Chunru Lin

Affiliations

Soon will be listed here.

Abstract

Cancer metastasis is a multistep process that requires cancer cells to leave the primary site, survive in the blood stream, and finally colonize at a distant organ. It is the major cause of cancer morbidity and mortality. The organ-specific colonization requires close interaction and communication between cancer cells and host organs. Noncoding RNAs represent the majority of the transcriptome, with long noncoding RNAs (lncRNAs) making up a significant proportion. It has been suggested that lncRNAs play a key role in all stages of tumorigenesis and metastasis. This review will provide an overview of how lncRNAs are involved in cancer cell colonization in specific organ sites and the underlying mechanisms as well as therapeutic strategies.

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