Surviving at a Distance: Organ-Specific Metastasis

Overview

Journal Trends Cancer

Publisher Cell Press

Specialty Oncology

Date 2017 Jul 26

PMID 28741564

Citations 268

Authors

Anna C Obenauf

Joan Massague

Affiliations

Soon will be listed here.

Abstract

The clinical manifestation of metastasis in a vital organ is the final stage of cancer progression and the main culprit of cancer-related mortality. Once established, metastasis is devastating, but only a small proportion of the cancer cells that leave a tumor succeed at infiltrating, surviving, and ultimately overtaking a distant organ. The bottlenecks that challenge cancer cells in newly invaded microenvironments are organ-specific and consequently demand distinct mechanisms for metastatic colonization. We review the metastatic traits that allow cancer cells to colonize distinct organ sites.

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