Emerging Biological Principles of Metastasis

Overview

Journal Cell

Publisher Cell Press

Specialty Cell Biology

Date 2017 Feb 11

PMID 28187288

Citations 1475

Authors

Arthur W Lambert

Diwakar R Pattabiraman

Robert A Weinberg

Affiliations

Soon will be listed here.

Abstract

Metastases account for the great majority of cancer-associated deaths, yet this complex process remains the least understood aspect of cancer biology. As the body of research concerning metastasis continues to grow at a rapid rate, the biological programs that underlie the dissemination and metastatic outgrowth of cancer cells are beginning to come into view. In this review we summarize the cellular and molecular mechanisms involved in metastasis, with a focus on carcinomas where the most is known, and we highlight the general principles of metastasis that have begun to emerge.

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