Establishment of Prognostic Signatures of N6-Methyladenosine-Related LncRNAs and Their Potential Functions in Hepatocellular Carcinoma Patients

Overview

Journal Front Oncol

Specialty Oncology

Date 2022 Jun 23

PMID 35734590

Authors

Xianbin Wu

Zhejun Deng

Xiaomin Liao

Xianxian Ruan

Nanfang Qu

Lixing Pang

Xiaoyan Shi

Shanyu Qin

Haixing Jiang

Affiliations

Soon will be listed here.

Abstract

N6-methyladenosine (m6a)-related mRNAs and lncRNAs have been explored for their functions in several cancers. The present study aimed to identify potential signatures of m6a-related lncRNAs in hepatocellular carcinoma (HCC). We downloaded the expression and clinical data from The Cancer Genome Atlas (TCGA) database. The interacted mRNAs and lncRNAs, prognosis-related lncRNAs, potential metabolic pathways of lncRNAs, immune infiltration of various cells, and CD274 (PD-L1) -related lncRNAs were analyzed. Then, experiments explored the role of AC012073.1 (LOC105377626) in HCC cell lines. We found that candidate 14 lncRNA signatures play functions in HCC maybe by affecting immune infiltration, cell cycle, Notch signaling pathway, etc. LncRNA AC012073.1 (LOC105377626) functions as oncogenic roles in affecting HCC prognosis.

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