Aerobic Glycolysis and High Level of Lactate in Cancer Metabolism and Microenvironment

Overview

Journal Genes Dis

Date 2018 Sep 28

PMID 30258905

Citations 99

Authors

Bo Jiang

Affiliations

Soon will be listed here.

Abstract

Metabolic abnormalities is a hallmark of cancer. About 100 years ago, Nobel laureate Otto Heinrich Warburg first described high rate of glycolysis in cancer cells. Recently more and more novel opinions about cancer metabolism supplement to this hypothesis, consist of glucose uptake, lactic acid generation and secretion, acidification of the microenvironment and cancer immune evasion. Here we briefly review metabolic pathways generating lactate, and discuss the function of higher lactic acid in cancer microenvironments.

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