Exosome in Tumour Microenvironment: Overview of the Crosstalk Between Normal and Cancer Cells

Overview

Journal Biomed Res Int

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
General Medicine

Date 2014 Jun 26

PMID 24963475

Citations 119

Authors

Catarina Roma-Rodrigues

Alexandra R Fernandes

Pedro Viana Baptista

Affiliations

Soon will be listed here.

Abstract

Cancer development is a multistep process in which exosomes play important roles. Exosomes are small vesicles formed in vesicular bodies in the endosomal network. The major role of exosomes seems to be the transport of bioactive molecules between cells. Depending on the cell of origin, exosomes are implicated in the regulation of several cellular events, with phenotypic consequences in recipient cells. Cancer derived exosomes (CCEs) are important players in the formation of the tumour microenvironment by (i) enabling the escape of tumour cells to immunological system and help initiating the inflammatory response; (ii) acting in the differentiation of fibroblasts and mesenchymal cells into myofibroblasts; (iii) triggering the angiogenic process; and (iv) enhancing the metastatic evolution of the tumour by promoting epithelial to mesenchymal transformation of tumour cells and by preparing the tumour niche in the new anatomical location. Since the finding that exosomes content resembles that of the cell of origin, they may be regarded as suitable biomarkers for cancer diagnosis, allowing for diagnosis and prognosis via a minimal invasive procedure. Exosome involvement in cancer may open new avenues regarding therapeutics, such as vectors for targeted drug delivery.

Citing Articles

The Effect of Ionising Radiation on the Properties of Tumour-Derived Exosomes and Their Ability to Modify the Biology of Non-Irradiated Breast Cancer Cells-An In Vitro Study.

Lach M, Wroblewska J, Michalak M, Budny B, Wrotkowska E, Suchorska W Int J Mol Sci. 2025; 26(1.

PMID: 39796230 PMC: 11719956. DOI: 10.3390/ijms26010376.

Mutant p53-Mediated Tumor Secretome: Bridging Tumor Cells and Stromal Cells.

Qiu L, Ma Z, Wu X Genes (Basel). 2025; 15(12.

PMID: 39766882 PMC: 11675497. DOI: 10.3390/genes15121615.

Gastric cancer cell-derived exosomal miRNA-128-3p promotes angiogenesis by targeting SASH1.

Yan H, Cai X, Zhang J, Zhao H, Wu H, Zhang J Front Oncol. 2024; 14:1440996.

PMID: 39664191 PMC: 11631727. DOI: 10.3389/fonc.2024.1440996.

Focusing on exosomes to overcome the existing bottlenecks of CAR-T cell therapy.

Zhang S, Peng L, Chen Y, Xu Y, Moradi V Inflamm Regen. 2024; 44(1):45.

PMID: 39490997 PMC: 11533312. DOI: 10.1186/s41232-024-00358-x.

Emerging roles of CircRNA-miRNA networks in cancer development and therapeutic response.

Hashemi M, Khosroshahi E, Daneii P, Hassanpoor A, Eslami M, Koohpar Z Noncoding RNA Res. 2024; 10:98-115.

PMID: 39351450 PMC: 11440256. DOI: 10.1016/j.ncrna.2024.09.006.

References

Andre F, Schartz N, Movassagh M, Flament C, Pautier P, Morice P . Malignant effusions and immunogenic tumour-derived exosomes. Lancet. 2002; 360(9329):295-305. DOI: 10.1016/S0140-6736(02)09552-1. View

Gajos-Michniewicz A, Duechler M, Czyz M . MiRNA in melanoma-derived exosomes. Cancer Lett. 2014; 347(1):29-37. DOI: 10.1016/j.canlet.2014.02.004. View

Filipowicz W, Bhattacharyya S, Sonenberg N . Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?. Nat Rev Genet. 2008; 9(2):102-14. DOI: 10.1038/nrg2290. View

Peinado H, Aleckovic M, Lavotshkin S, Matei I, Costa-Silva B, Moreno-Bueno G . Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. Nat Med. 2012; 18(6):883-91. PMC: 3645291. DOI: 10.1038/nm.2753. View

El Andaloussi S, Mager I, Breakefield X, Wood M . Extracellular vesicles: biology and emerging therapeutic opportunities. Nat Rev Drug Discov. 2013; 12(5):347-57. DOI: 10.1038/nrd3978. View

Katoh M . Therapeutics targeting angiogenesis: genetics and epigenetics, extracellular miRNAs and signaling networks (Review). Int J Mol Med. 2013; 32(4):763-7. PMC: 3812243. DOI: 10.3892/ijmm.2013.1444. View

Dijkstra S, Birker I, Smit F, Leyten G, de Reijke T, van Oort I . Prostate cancer biomarker profiles in urinary sediments and exosomes. J Urol. 2013; 191(4):1132-8. DOI: 10.1016/j.juro.2013.11.001. View

Kucharzewska P, Belting M . Emerging roles of extracellular vesicles in the adaptive response of tumour cells to microenvironmental stress. J Extracell Vesicles. 2013; 2. PMC: 3760648. DOI: 10.3402/jev.v2i0.20304. View

Geiger T, Peeper D . Metastasis mechanisms. Biochim Biophys Acta. 2009; 1796(2):293-308. DOI: 10.1016/j.bbcan.2009.07.006. View

10.

Keller S, Sanderson M, Stoeck A, Altevogt P . Exosomes: from biogenesis and secretion to biological function. Immunol Lett. 2006; 107(2):102-8. DOI: 10.1016/j.imlet.2006.09.005. View

11.

Suetsugu A, Honma K, Saji S, Moriwaki H, Ochiya T, Hoffman R . Imaging exosome transfer from breast cancer cells to stroma at metastatic sites in orthotopic nude-mouse models. Adv Drug Deliv Rev. 2012; 65(3):383-90. DOI: 10.1016/j.addr.2012.08.007. View

12.

Franzen C, Simms P, Van Huis A, Foreman K, Kuo P, Gupta G . Characterization of uptake and internalization of exosomes by bladder cancer cells. Biomed Res Int. 2014; 2014:619829. PMC: 3915764. DOI: 10.1155/2014/619829. View

13.

Hanahan D, Weinberg R . Hallmarks of cancer: the next generation. Cell. 2011; 144(5):646-74. DOI: 10.1016/j.cell.2011.02.013. View

14.

Escudier B, Dorval T, Chaput N, Andre F, Caby M, Novault S . Vaccination of metastatic melanoma patients with autologous dendritic cell (DC) derived-exosomes: results of thefirst phase I clinical trial. J Transl Med. 2005; 3(1):10. PMC: 554765. DOI: 10.1186/1479-5876-3-10. View

15.

Morse M, Garst J, Osada T, Khan S, Hobeika A, Clay T . A phase I study of dexosome immunotherapy in patients with advanced non-small cell lung cancer. J Transl Med. 2005; 3(1):9. PMC: 551593. DOI: 10.1186/1479-5876-3-9. View

16.

Fleming A, Sampey G, Chung M, Bailey C, van Hoek M, Kashanchi F . The carrying pigeons of the cell: exosomes and their role in infectious diseases caused by human pathogens. Pathog Dis. 2014; 71(2):109-20. DOI: 10.1111/2049-632X.12135. View

17.

Ohno S, Ishikawa A, Kuroda M . Roles of exosomes and microvesicles in disease pathogenesis. Adv Drug Deliv Rev. 2012; 65(3):398-401. DOI: 10.1016/j.addr.2012.07.019. View

18.

Yu X, Harris S, Levine A . The regulation of exosome secretion: a novel function of the p53 protein. Cancer Res. 2006; 66(9):4795-801. DOI: 10.1158/0008-5472.CAN-05-4579. View

19.

Hannafon B, Ding W . Intercellular communication by exosome-derived microRNAs in cancer. Int J Mol Sci. 2013; 14(7):14240-69. PMC: 3742242. DOI: 10.3390/ijms140714240. View

20.

Camacho L, Guerrero P, Marchetti D . MicroRNA and protein profiling of brain metastasis competent cell-derived exosomes. PLoS One. 2013; 8(9):e73790. PMC: 3774795. DOI: 10.1371/journal.pone.0073790. View