As a Predictive Biomarker and Its Association with the Infiltration of Immune Cells in Pancreatic Adenocarcinoma

Overview

Journal J Gastrointest Oncol

Date 2024 Sep 16

PMID 39279982

Authors

Qiuqing Zheng

Yingjun Xie

Luyin Xu

Delian Chen

Jianfeng Wu

Shuxun Liu

Lili Wu

Peiwei Fang

Fajun Xie

Affiliations

Soon will be listed here.

Abstract

Background: Lactate dehydrogenase A () plays a crucial role in the final step of anaerobic glycolysis, converting L-lactate and NAD to pyruvate and nicotinamide adenine dinucleotide (NADH). Its high expression has been linked to tumorigenesis and patient survival in various human cancers. However, the full implications of 's role and its correlation with clinicopathological features in pancreatic adenocarcinoma (PAAD) remain to be fully understood. This study was thus conducted to elucidate the specific functions of in PAAD, with the aim of providing more robust evidence for clinical diagnosis and treatment.

Methods: In an extensive systems analysis, we searched through numerous databases, including The Cancer Genome Atlas (TCGA) and Oncomine. Our objective was to clarify the clinical implications and functional role of in PAAD. Bioinformatics was used to identify the biological function of expression and its correlation with tumor immune status.

Results: Our analysis revealed that the gene is overexpressed in PAAD and that this upregulation was associated with a worse patient prognosis. Through gene set enrichment analysis, we found that 's influence on PAAD is linked to signaling pathways involving Kirsten rat sarcoma viral oncogene homolog (), transforming growth factor-β (), and hypoxia inducible factor-1 (). Mutation of could upregulate its own expression and was positively correlated with expression. Moreover, our data demonstrated that expression was linked to immune infiltration and poor prognosis in PAAD, indicating its role in disease pathogenesis. Overexpression of may suppress tumor immunity, suggesting it as a potential target for the diagnosis and treatment of PAAD, thus providing new insights into managing this aggressive cancer.

Conclusions: Overall, our results showed that as a prognostic biomarker could serve as a novel target for future PAAD immunotherapy.

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