A Potential Therapeutic Target: The Role of Neutrophils in the Central Nervous System

Overview

Journal Brain Behav Immun Health

Date 2023 Sep 28

PMID 37767236

Authors

Isabel Salken

Jose Javier Provencio

Aminata P Coulibaly

Affiliations

Soon will be listed here.

Abstract

Neutrophils play a critical role in immune defense as the first recruited and most abundant leukocytes in the innate immune system. As such, regulation of neutrophil effector functions have strong implications on immunity. These cells display a wide heterogeneity of function, including both inflammatory and immunomodulatory roles. Neutrophils commonly infiltrate the central nervous system (CNS) in response to varied pathological conditions. There is still little understanding of the role these cells play in the CNS in such conditions. In the present review, we will summarize what is known of neutrophil's role in cancer and Alzheimer's disease (AD), with a focus on highlighting the gaps in our understanding.

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