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Reactivity Patterns to Human Rotavirus Strains of a Monoclonal Antibody Against VP2, a Component of the Inner Capsid of Rotavirus. Brief Report

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Journal Arch Virol
Specialty Microbiology
Date 1986 Jan 1
PMID 3002300
Citations 16
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Abstract

A non-neutralizing monoclonal antibody (YO-60) against human rotavirus was found to be directed to VP2 (90,000-dalton protein), one of the two major components of the inner capsid. The reactivity patterns of the YO-60 antibody were very similar, though not identical, to those of subgroup II-specific YO-5 monoclonal antibody directed to VP6 (42,000-dalton protein), the other major component of the inner capsid. These results indicated the possible presence of a subgroup-specific antigen on VP2 in addition to the one on VP6.

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