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Association of Polymorphisms in MALAT1 with Risk of Coronary Atherosclerotic Heart Disease in a Chinese Population

Overview

Overview

Journal Lipids Health Dis

Publisher Biomed Central

Specialties Biochemistry
Endocrinology

Date 2018 Apr 11

PMID 29631611

Citations 29

Authors

Authors

Genan Wang

Yaxiong Li

Yong Peng

Jian Tang

Hua Li

Affiliations

Affiliations

Soon will be listed here.

Abstract

Background: Metastasis associated lung adenocarcinoma transcript 1 (MALAT1) plays an important role in vascular remodeling. Down-regulation of MALAT1 can inhibit the proliferation of vascular endothelial cells and vascular smooth muscle cells, reduce cardiomyocyte apoptosis and improve left ventricular function, which is closely linked to numerous pathological processes such as coronary atherosclerotic heart disease (CAD). The aim of this study was to investigate whether polymorphisms in MALAT1 were associated with the susceptibility to CAD.

Methods: A total of 508 CAD patients and 562 age-, gender-, and ethnicity-matched controls were enrolled in this study. Four polymorphisms in MALAT1 (i.e., rs11227209, rs619586, rs664589, and rs3200401) were genotyped using a TaqMan allelic discrimination assay.

Results: The rs619586 AG/GG genotypes and G allele were associated with a reduced risk of CAD (AG/GG vs. AA: adjusted OR = 0.66, 95% CI: 0.48-0.91; G vs. A: adjusted OR = 0.68, 95% CI: 0.51-0.90). Stratification analyses showed that CAD patients with rs11227209 CG/GG, rs619586 AG/GG, and rs3200401 CT/TT genotypes exhibited lower levels of TCH (P = 0.02, 0.04, and 0.02, respectively). Moreover, CGCC haplotype was associated with a decreased risk of CAD (OR = 0.28, 95% CI: 0.16-0.48). Multivariate logistic regression analysis identified some independent risk factors for CAD, including rs619586 and rs664589. Subsequent combined analysis showed that the combined genotypes of rs619586AG/GG and rs664589CC were associated with a reduced risk of CAD (OR = 0.29; 95%CI, 0.16-0.53).

Conclusions: These findings indicate that rs619586AG/GG genotypes in MALAT1 may protect against the occurrence of CAD.

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References

1.

Liu Y, Pan S, Liu L, Zhai X, Liu J, Wen J . A genetic variant in long non-coding RNA HULC contributes to risk of HBV-related hepatocellular carcinoma in a Chinese population. PLoS One. 2012; 7(4):e35145. PMC: 3320879. DOI: 10.1371/journal.pone.0035145. View

2.

Gong W, Peng J, Yin J, Li X, Zheng W, Xiao L . Association between well-characterized lung cancer lncRNA polymorphisms and platinum-based chemotherapy toxicity in Chinese patients with lung cancer. Acta Pharmacol Sin. 2017; 38(4):581-590. PMC: 5386317. DOI: 10.1038/aps.2016.164. View

3.

. Global, regional, and national age-sex specific mortality for 264 causes of death, 1980-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet. 2017; 390(10100):1151-1210. PMC: 5605883. DOI: 10.1016/S0140-6736(17)32152-9. View

4.

Chobanian A, Bakris G, Black H, Cushman W, Green L, Izzo Jr J . Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension. 2003; 42(6):1206-52. DOI: 10.1161/01.HYP.0000107251.49515.c2. View

5.

Li C, Miao R, Liu S, Wan Y, Zhang S, Deng Y . Down-regulation of miR-146b-5p by long noncoding RNA MALAT1 in hepatocellular carcinoma promotes cancer growth and metastasis. Oncotarget. 2017; 8(17):28683-28695. PMC: 5438683. DOI: 10.18632/oncotarget.15640. View

6.

Charlson F, Moran A, Freedman G, Norman R, Stapelberg N, Baxter A . The contribution of major depression to the global burden of ischemic heart disease: a comparative risk assessment. BMC Med. 2013; 11:250. PMC: 4222499. DOI: 10.1186/1741-7015-11-250. View

7.

Arslan S, Berkan O, Lalem T, Ozbilum N, Goksel S, Korkmaz O . Long non-coding RNAs in the atherosclerotic plaque. Atherosclerosis. 2017; 266:176-181. DOI: 10.1016/j.atherosclerosis.2017.10.012. View

8.

Mehta P, Wei J, Wenger N . Ischemic heart disease in women: a focus on risk factors. Trends Cardiovasc Med. 2014; 25(2):140-51. PMC: 4336825. DOI: 10.1016/j.tcm.2014.10.005. View

9.

Pjanic M, Miller C, Wirka R, Kim J, DiRenzo D, Quertermous T . Genetics and Genomics of Coronary Artery Disease. Curr Cardiol Rep. 2016; 18(10):102. PMC: 5872834. DOI: 10.1007/s11886-016-0777-y. View

10.

Mozzini C, Fratta Pasini A, Garbin U, Stranieri C, Pasini A, Vallerio P . Increased endoplasmic reticulum stress and Nrf2 repression in peripheral blood mononuclear cells of patients with stable coronary artery disease. Free Radic Biol Med. 2013; 68:178-85. DOI: 10.1016/j.freeradbiomed.2013.12.017. View

11.

AbdulAzeez S, Al-Nafie A, Al-Shehri A, Borgio J, Baranova E, Al-Madan M . Intronic Polymorphisms in the CDKN2B-AS1 Gene Are Strongly Associated with the Risk of Myocardial Infarction and Coronary Artery Disease in the Saudi Population. Int J Mol Sci. 2016; 17(3):395. PMC: 4813250. DOI: 10.3390/ijms17030395. View

12.

Cheng J, Cai M, Chen Y, Li Z, Tang S, Yang X . Variants in ANRIL gene correlated with its expression contribute to myocardial infarction risk. Oncotarget. 2017; 8(8):12607-12619. PMC: 5355039. DOI: 10.18632/oncotarget.14721. View

13.

Arun G, Diermeier S, Akerman M, Chang K, Wilkinson J, Hearn S . Differentiation of mammary tumors and reduction in metastasis upon Malat1 lncRNA loss. Genes Dev. 2015; 30(1):34-51. PMC: 4701977. DOI: 10.1101/gad.270959.115. View

14.

Yu C, Xu T, Assoian R, Rader D . Mining the Stiffness-Sensitive Transcriptome in Human Vascular Smooth Muscle Cells Identifies Long Noncoding RNA Stiffness Regulators. Arterioscler Thromb Vasc Biol. 2017; 38(1):164-173. PMC: 5881588. DOI: 10.1161/ATVBAHA.117.310237. View

15.

Vausort M, Wagner D, Devaux Y . Long noncoding RNAs in patients with acute myocardial infarction. Circ Res. 2014; 115(7):668-77. DOI: 10.1161/CIRCRESAHA.115.303836. View

16.

McPherson R, Tybjaerg-Hansen A . Genetics of Coronary Artery Disease. Circ Res. 2016; 118(4):564-78. DOI: 10.1161/CIRCRESAHA.115.306566. View

17.

Strom J, Chen Q . Loss of Nrf2 promotes rapid progression to heart failure following myocardial infarction. Toxicol Appl Pharmacol. 2017; 327:52-58. DOI: 10.1016/j.taap.2017.03.025. View

18.

Chen T, Wu B, Lin R . Association of apelin and apelin receptor with the risk of coronary artery disease: a meta-analysis of observational studies. Oncotarget. 2017; 8(34):57345-57355. PMC: 5593646. DOI: 10.18632/oncotarget.17360. View

19.

Zhuo Y, Zeng Q, Zhang P, Li G, Xie Q, Cheng Y . Functional polymorphism of lncRNA MALAT1 contributes to pulmonary arterial hypertension susceptibility in Chinese people. Clin Chem Lab Med. 2016; 55(1):38-46. DOI: 10.1515/cclm-2016-0056. View

20.

Shanker J, Arvind P, Jambunathan S, Nair J, Kakkar V . Genetic analysis of the 9p21.3 CAD risk locus in Asian Indians. Thromb Haemost. 2014; 111(5):960-9. DOI: 10.1160/TH13-08-0706. View