A Genetic Variant in Long Non-coding RNA HULC Contributes to Risk of HBV-related Hepatocellular Carcinoma in a Chinese Population

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2012 Apr 12

PMID 22493738

Citations 88

Authors

Yao Liu

Shandong Pan

Li Liu

Xiangjun Zhai

Jibin Liu

Juan Wen

Yixin Zhang

Jianguo Chen

Hongbing Shen

Zhibin Hu

Affiliations

Soon will be listed here.

Abstract

Background: Recently, several studies have demonstrated that two long non-coding RNAs (lncRNAs), HULC and MALAT1, may participate in hepatocellular carcinoma (HCC) development and progression. However, genetic variations in the two lncRNAs and their associations with HCC susceptibility have not been reported. In this study, we hypothesized that single nucleotide polymorphisms (SNPs) in HULC and MALAT1 may contribute to HCC risk.

Methods: We conducted a case-control study and genotyped two SNPs, rs7763881 in HULC and rs619586 in MALAT1, in 1300 HBV positive HCC patients, 1344 HBV persistent carriers and 1344 subjects with HBV natural clearance to test the associations between the two SNPs and susceptibility to HCC and HBV chronic infection.

Results: The variant genotypes of rs7763881 were significantly associated with decreased HCC risk in a dominant genetic model [AC/CC vs. AA: adjusted odds ration (OR) = 0.81, 95% confidence intervals (CIs) = 0.68-0.97, P = 0.022]. Furthermore, the variant genotypes of rs619586 was associated with decreased HCC risk with a borderline significance (AG/GG vs. AA: adjusted OR = 0.81, 95% CIs = 0.65-1.01, P = 0.057). However, no significant association was found between the two SNPs and HBV clearance.

Conclusions: The variant genotypes of rs7763881 in HULC may contribute to decreased susceptibility to HCC in HBV persistent carriers.

Citing Articles

The expression and function of long noncoding RNAs in hepatocellular carcinoma.

Du J, Su Y, Gao J, Tai Y Cancer Innov. 2023; 2(6):488-499.

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LncRNA MALAT1 Expression Regulates Breast Cancer Progression via PI3K/AKT/mTOR Pathway Modulation.

Naveed M, Malik A, Anjum H, Ijaz B Biochem Genet. 2023; 62(5):3421-3438.

PMID: 38110774 DOI: 10.1007/s10528-023-10592-6.

Non-coding RNA and hepatitis B virus-related hepatocellular carcinoma: A bibliometric analysis and systematic review.

Yan L, Liu A, Jiang L, Wang B Front Med (Lausanne). 2022; 9:995943.

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MALAT1 Polymorphisms and Lung Cancer Susceptibility in a Chinese Northeast Han Population.

Tong G, Tong W, He R, Cui Z, Li S, Zhou B Int J Med Sci. 2022; 19(8):1300-1306.

PMID: 35928715 PMC: 9346381. DOI: 10.7150/ijms.73026.

Genetic polymorphisms in the miR-372 (rs12983273) and LncRNA HULC (rs7763881) genes and susceptibility to Hepatitis B virus (HBV) infection.

Shahen S, Elshenawy S, Mohamed S, Talaat R Mol Biol Rep. 2021; 48(12):7901-7906.

PMID: 34677712 DOI: 10.1007/s11033-021-06818-8.

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