MALAT1 Polymorphisms and Lung Cancer Susceptibility in a Chinese Northeast Han Population

Overview

Journal Int J Med Sci

Specialty General Medicine

Date 2022 Aug 5

PMID 35928715

Authors

Guanghui Tong

Weiwei Tong

Ran He

Zhigang Cui

Sixuan Li

Baosen Zhou

Zhihua Yin

Affiliations

Soon will be listed here.

Abstract

LncRNA MALAT1 (metastasis-associated lung adenocarcinoma transcript 1) was competitive endogenous RNA (ceRNA) involved in various molecular processes for metastasis development in lung cancer. Single nucleotide polymorphisms (SNPs) in MALAT1 gene might be predictive markers for lung cancer. In our study, we selected rs619586 and rs3200401 in MALAT1 gene to explore their effects on lung cancer susceptibility. The case-control study included 444 lung cancer cases and 460 healthy controls. Genotyping was performed by Taqman allelic discrimination method. Logistic regression, Student -test, and Chi-square test ( ) were used to analyze the data. The findings of the study showed that rs3200401 was significantly associated with the risk of non-small cell lung cancer (NSCLC) and lung squamous cell carcinoma (LUSC). Compared with homozygous CC genotype, CT heterozygous genotype decreased risk of NSCLC ( = 0.034) and LUSC ( = 0.025). In addition, no statistical association was detected between rs619586 and lung cancer susceptibility. The interactions between genes and cigarette smoking were discovered via crossover analysis. However, there were no remarkable gene-environment interactions in additive and multiplicative model. Rs3200401 in lncRNA MALAT1 was associated with the susceptibility of non-small-cell lung cancer and lung squamous cell carcinoma. The gene-environmental (cigarette smoking) interactions were not notable.

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