The Association of Thyroid Disease and Oral Lichen Planus: A Literature Review and Meta-analysis

Overview

Journal Front Endocrinol (Lausanne)

Specialty Endocrinology

Date 2017 Nov 25

PMID 29170653

Citations 19

Authors

Dan Li

Jin Li

Chunlei Li

Qianming Chen

Hong Hua

Affiliations

Soon will be listed here.

Abstract

Background: The objective of this study was to systemically evaluate the association between oral lichen planus (OLP) and thyroid disease.

Method: Eleven electronic databases were searched for any clinical study published up until August 2016 that explored an association between OLP and thyroid disease, complemented with manual searching. The titles and abstracts of all studies identified from the electronic searches were then assessed independently to determine inclusion of the study. The population of interest was patients with OLP, and the exposure was the presence of thyroid disease in OLP patients. Statistical analyses were conducted using Review Manager 5.2. The odds ratios (OR) and 95% confidence intervals (CIs) were calculated to evaluate the association between OLP and thyroid disease.

Results: Eight studies were included for review, and of these, four case-control studies were included in the final meta-analysis. The mean Newcastle-Ottawa Scale score evaluating the methodological quality of the four studies was 6.5. The OR was 2.10 (95% CI: 1.47-3.01), indicating a statistically significant difference in the prevalence of thyroid disease between the OLP and control groups. Heterogeneity was satisfactory ( = 0%, <25%). An approximately symmetrical funnel plot suggested no obvious publication bias. Two articles showed a higher correlation between OLP and hypothyroidism (OR 1.83, 95% CI: 1.16-2.89), with satisfactory heterogeneity ( = 0%, <25%).

Conclusion: This meta-analysis indicated a significantly high prevalence of thyroid disease among OLP patients compared with controls, suggesting that routine screening for thyroid disease could be beneficial to OLP patients. However, due to the small number of studies included, further studies are needed to confirm the results.

Citing Articles

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Oral and non-oral lichen planus show genetic heterogeneity and differential risk for autoimmune disease and oral cancer.

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Parvini P, Obreja K, Cafferata E, Aini T, Lermen Y, Begic A BMC Oral Health. 2024; 24(1):547.

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Manchanda Y, Rathi S, Joshi A, Das S Indian Dermatol Online J. 2024; 15(1):8-23.

PMID: 38283029 PMC: 10810384. DOI: 10.4103/idoj.idoj_652_22.

References

McCartan B, Healy C . The reported prevalence of oral lichen planus: a review and critique. J Oral Pathol Med. 2008; 37(8):447-53. DOI: 10.1111/j.1600-0714.2008.00662.x. View

Garcia-Pola M, Llorente-Pendas S, Seoane-Romero J, Berasaluce M, Garcia-Martin J . Thyroid Disease and Oral Lichen Planus as Comorbidity: A Prospective Case-Control Study. Dermatology. 2016; 232(2):214-9. DOI: 10.1159/000442438. View

Bermejo-Fenoll A, Lopez-Jornet P . Familial oral lichen planus: presentation of six families. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006; 102(2):e12-5. DOI: 10.1016/j.tripleo.2006.03.016. View

Brix T, Kyvik K, Christensen K, Hegedus L . Evidence for a major role of heredity in Graves' disease: a population-based study of two Danish twin cohorts. J Clin Endocrinol Metab. 2001; 86(2):930-4. DOI: 10.1210/jcem.86.2.7242. View

Kesic L, Obradovic R, Mihailovic D, Radicevic G, Stankovic S, Todorovic K . Incidence and treatment outcome of oral lichen planus in southeast Serbia in a 10-year period (1997-2007). Vojnosanit Pregl. 2009; 66(6):435-9. View

Olson M, Rogers 3rd R, Bruce A . Oral lichen planus. Clin Dermatol. 2016; 34(4):495-504. DOI: 10.1016/j.clindermatol.2016.02.023. View

Kurgansky D, Burnett J . Widespread lichen planus in association with Turner's syndrome and multiple endocrinopathies. Cutis. 1994; 54(2):108-10. View

Soto Araya M, Rojas Alcayaga G, Esguep A . Association between psychological disorders and the presence of Oral lichen planus, Burning mouth syndrome and Recurrent aphthous stomatitis. Med Oral. 2004; 9(1):1-7. View

Siponen M, Huuskonen L, Laara E, Salo T . Association of oral lichen planus with thyroid disease in a Finnish population: a retrospective case-control study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010; 110(3):319-24. DOI: 10.1016/j.tripleo.2010.04.001. View

10.

Vucicevic Boras V, Savage N, Brailo V, Skrinjar I, Valter K, Alajbeg I . The significance of oral and systemic factors in Australian and Croatian patients with oral lichen planus. Acta Dermatovenerol Croat. 2014; 22(2):97-102. View

11.

Shamseer L, Moher D, Clarke M, Ghersi D, Liberati A, Petticrew M . Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation. BMJ. 2015; 350:g7647. DOI: 10.1136/bmj.g7647. View

12.

Iglesias P, Bajo M, Selgas R, Diez J . Thyroid dysfunction and kidney disease: An update. Rev Endocr Metab Disord. 2016; 18(1):131-144. DOI: 10.1007/s11154-016-9395-7. View

13.

Yu-Fong Chang J, Chiang C, Hsiao C, Sun A . Significantly higher frequencies of presence of serum autoantibodies in Chinese patients with oral lichen planus. J Oral Pathol Med. 2008; 38(1):48-54. DOI: 10.1111/j.1600-0714.2008.00686.x. View

14.

McLeod D, Cooper D . The incidence and prevalence of thyroid autoimmunity. Endocrine. 2012; 42(2):252-65. DOI: 10.1007/s12020-012-9703-2. View

15.

Iddah M, Macharia B, Ngwena A, Keter A, Ofulla A . Thryroid hormones and hematological indices levels in thyroid disorders patients at moi teaching and referral hospital, Western kenya. ISRN Endocrinol. 2013; 2013:385940. PMC: 3649456. DOI: 10.1155/2013/385940. View

16.

Guarneri F, Giuffrida R, Di Bari F, Cannavo S, Benvenga S . Thyroid Autoimmunity and Lichen. Front Endocrinol (Lausanne). 2017; 8:146. PMC: 5484774. DOI: 10.3389/fendo.2017.00146. View

17.

Robledo-Sierra J, Mattsson U, Jontell M . Use of systemic medication in patients with oral lichen planus - a possible association with hypothyroidism. Oral Dis. 2012; 19(3):313-9. DOI: 10.1111/odi.12009. View

18.

Lauritano D, Arrica M, Lucchese A, Valente M, Pannone G, Lajolo C . Oral lichen planus clinical characteristics in Italian patients: a retrospective analysis. Head Face Med. 2016; 12:18. PMC: 4845340. DOI: 10.1186/s13005-016-0115-z. View

19.

Ivanovski K, Nakova M, Warburton G, Pesevska S, Filipovska A, Nares S . Psychological profile in oral lichen planus. J Clin Periodontol. 2005; 32(10):1034-40. DOI: 10.1111/j.1600-051X.2005.00829.x. View

20.

Eisen D, Carrozzo M, Bagan Sebastian J, Thongprasom K . Number V Oral lichen planus: clinical features and management. Oral Dis. 2005; 11(6):338-49. DOI: 10.1111/j.1601-0825.2005.01142.x. View