Possible Mechanisms Involved in the Cooccurrence of Oral Lichen Planus and Hashimoto's Thyroiditis

Overview

Journal Mediators Inflamm

Publisher Wiley

Specialties Biochemistry
Pathology

Date 2020 Feb 25

PMID 32089646

Citations 7

Authors

Peiyao Wu

Shuhan Luo

Tao Zhou

Rui Wang

Xuemei Qiu

Peiyang Yuan

Yuqing Yang

Qi Han

Lu Jiang

Affiliations

Soon will be listed here.

Abstract

Oral lichen planus (OLP) is a chronic inflammatory oral mucosal disorder mediated by T cells, with a multifactorial etiology. Hashimoto's thyroiditis (HT) is a common autoimmune disease characterized by hypothyroidism. Although many clinical studies conducted over the past several decades have reported the cooccurrence of OLP and HT, the underlying mechanism remains unclear. This review summarizes potential mechanisms that might be involved in the cooccurrence of OLP and HT. We find that OLP and HT share a common or overlapping pathogenesis in terms of immune, heredity, environmental, and hormonal factors, which might cause cooccurrence. Furthermore, considering the latency of HT, a routine screen for thyroid diseases, particularly HT, is suggested for confirmed OLP patients.

Citing Articles

Immune-Molecular Link between Thyroid and Skin Autoimmune Diseases: A Narrative Review.

Carlucci P, Spataro F, Cristallo M, Di Gioacchino M, Nettis E, Gangemi S J Clin Med. 2024; 13(18).

PMID: 39337081 PMC: 11433455. DOI: 10.3390/jcm13185594.

Oral and non-oral lichen planus show genetic heterogeneity and differential risk for autoimmune disease and oral cancer.

Reeve M, Vehvilainen M, Luo S, Ritari J, Karjalainen J, Gracia-Tabuenca J Am J Hum Genet. 2024; 111(6):1047-1060.

PMID: 38776927 PMC: 11179409. DOI: 10.1016/j.ajhg.2024.04.020.

Oral Lichen Planus: An Updated Review of Etiopathogenesis, Clinical Presentation, and Management.

Manchanda Y, Rathi S, Joshi A, Das S Indian Dermatol Online J. 2024; 15(1):8-23.

PMID: 38283029 PMC: 10810384. DOI: 10.4103/idoj.idoj_652_22.

Crossroads between Skin and Endocrine Glands: The Interplay of Lichen Planus with Thyroid Anomalies.

Radu A, Carsote M, Nistor C, Dumitrascu M, Sandru F Biomedicines. 2024; 12(1).

PMID: 38255184 PMC: 10813575. DOI: 10.3390/biomedicines12010077.

The Correlation between Oral Lichen Planus and Thyroid Pathologies: A Retrospective Study in a Sample of Italian Population.

Piloni S, Ferragina F, Barca I, Kallaverja E, Cristofaro M Eur J Dent. 2023; 18(2):510-516.

PMID: 37729935 PMC: 11132789. DOI: 10.1055/s-0043-1772247.

References

Lechner J, Rudi T, von Baehr V . Osteoimmunology of tumor necrosis factor-alpha, IL-6, and RANTES/CCL5: a review of known and poorly understood inflammatory patterns in osteonecrosis. Clin Cosmet Investig Dent. 2018; 10:251-262. PMC: 6233471. DOI: 10.2147/CCIDE.S184498. View

Mittrucker H, Visekruna A, Huber M . Heterogeneity in the differentiation and function of CD8⁺ T cells. Arch Immunol Ther Exp (Warsz). 2014; 62(6):449-58. DOI: 10.1007/s00005-014-0293-y. View

Li C, Yuan J, Zhu Y, Yang X, Wang Q, Xu J . Imbalance of Th17/Treg in Different Subtypes of Autoimmune Thyroid Diseases. Cell Physiol Biochem. 2016; 40(1-2):245-252. DOI: 10.1159/000452541. View

Alikhani M, Ghalaiani P, Askariyan E, Khunsaraki Z, Tavangar A, Naderi A . Association between the clinical severity of oral lichen planus and anti-TPO level in thyroid patients. Braz Oral Res. 2017; 31:e10. DOI: 10.1590/1807-3107BOR-2017.vol31.0010. View

Ahmed R, Al-Shaikh S, Akhtar M . Hashimoto thyroiditis: a century later. Adv Anat Pathol. 2012; 19(3):181-6. DOI: 10.1097/PAP.0b013e3182534868. View

Tan Y, Li Q, Zhang J, Du G, Lu R, Zhou G . Increased circulating CXCR5 CD4 T follicular helper-like cells in oral lichen planus. J Oral Pathol Med. 2017; 46(9):803-809. DOI: 10.1111/jop.12550. View

Kurgansky D, Burnett J . Widespread lichen planus in association with Turner's syndrome and multiple endocrinopathies. Cutis. 1994; 54(2):108-10. View

Dong Y, Fu D . Autoimmune thyroid disease: mechanism, genetics and current knowledge. Eur Rev Med Pharmacol Sci. 2014; 18(23):3611-8. View

Bai X, Sun J, Wang W, Shan Z, Zheng H, Li Y . Increased differentiation of Th22 cells in Hashimoto's thyroiditis. Endocr J. 2014; 61(12):1181-90. DOI: 10.1507/endocrj.EJ14-0265. View

10.

Karanikas G, Schuetz M, Wahl K, Paul M, Kontur S, Pietschmann P . Relation of anti-TPO autoantibody titre and T-lymphocyte cytokine production patterns in Hashimoto's thyroiditis. Clin Endocrinol (Oxf). 2005; 63(2):191-6. DOI: 10.1111/j.1365-2265.2005.02324.x. View

11.

Desai M, Brinton R . Autoimmune Disease in Women: Endocrine Transition and Risk Across the Lifespan. Front Endocrinol (Lausanne). 2019; 10:265. PMC: 6501433. DOI: 10.3389/fendo.2019.00265. View

12.

Wucherpfennig K, Strominger J . Selective binding of self peptides to disease-associated major histocompatibility complex (MHC) molecules: a mechanism for MHC-linked susceptibility to human autoimmune diseases. J Exp Med. 1995; 181(5):1597-601. PMC: 2191999. DOI: 10.1084/jem.181.5.1597. View

13.

Wang C, Li Y, Xue J, Ci H, Li L, Li L . [Correlation of Treg and IL-15 expression in the peripheral blood of patients with oral lichen planus]. Shanghai Kou Qiang Yi Xue. 2016; 25(4):438-442. View

14.

Ajjan R, Weetman A . The Pathogenesis of Hashimoto's Thyroiditis: Further Developments in our Understanding. Horm Metab Res. 2015; 47(10):702-10. DOI: 10.1055/s-0035-1548832. View

15.

Ghodratnama F, Wray D, Bagg J . Detection of serum antibodies against cytomegalovirus, varicella zoster virus and human herpesvirus 6 in patients with recurrent aphthous stomatitis. J Oral Pathol Med. 1999; 28(1):12-5. DOI: 10.1111/j.1600-0714.1999.tb01987.x. View

16.

Gurpinar A, Dogan Gunaydin S, Kilic C, Karaduman A . Association of serum cortisol and dehydroepiandrosterone sulfate (DHEAS) levels with psychological stress in patients with vitiligo. Turk J Med Sci. 2019; 49(3):832-837. PMC: 7018254. DOI: 10.3906/sag-1812-84. View

17.

Gregor C, Foeng J, Comerford I, McColl S . Chemokine-Driven CD4 T Cell Homing: New Concepts and Recent Advances. Adv Immunol. 2017; 135:119-181. DOI: 10.1016/bs.ai.2017.03.001. View

18.

Wang Y, Zhou J, Fu S, Wang C, Zhou B . A Study of Association Between Oral Lichen Planus and Immune Balance of Th1/Th2 Cells. Inflammation. 2015; 38(5):1874-9. DOI: 10.1007/s10753-015-0167-4. View

19.

Zhou T, Li D, Chen Q, Hua H, Li C . Correlation Between Oral Lichen Planus and Thyroid Disease in China: A Case-Control Study. Front Endocrinol (Lausanne). 2018; 9:330. PMC: 6015892. DOI: 10.3389/fendo.2018.00330. View

20.

Kundu R, Chain B, Coussens A, Khoo B, Noursadeghi M . Regulation of CYP27B1 and CYP24A1 hydroxylases limits cell-autonomous activation of vitamin D in dendritic cells. Eur J Immunol. 2014; 44(6):1781-90. DOI: 10.1002/eji.201344157. View