The Incidence and Prevalence of Thyroid Autoimmunity

Overview

Journal Endocrine

Specialty Endocrinology

Date 2012 May 31

PMID 22644837

Citations 233

Authors

Donald S A McLeod

David S Cooper

Affiliations

Soon will be listed here.

Abstract

The thyroid gland is the most common organ affected by autoimmune disease. Other autoimmune diseases, most notably type 1 diabetes mellitus, are increasing in incidence. It is unknown whether autoimmune thyroid diseases are following the same pattern. This review summarizes studies of autoimmune thyroid disease incidence and prevalence since 1950, not only for these measures of occurrences, but also for commenting on identified risk factors for thyroid autoimmunity. We find that incidence of autoimmune thyroid disease is currently higher than in historic series although the studies are so variable in design, patient population, disease definition, and laboratory methods that it is impossible to tell whether this difference is real. Further research is required to assess the possibility of changing disease patterns of autoimmune thyroid disease as opposed to simple changes in diagnostic thresholds.

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References

Konno N, Yuri K, Taguchi H, Miura K, Taguchi S, Hagiwara K . Screening for thyroid diseases in an iodine sufficient area with sensitive thyrotrophin assays, and serum thyroid autoantibody and urinary iodide determinations. Clin Endocrinol (Oxf). 1993; 38(3):273-81. DOI: 10.1111/j.1365-2265.1993.tb01006.x. View

Holm I, Manson J, Michels K, Alexander E, Willett W, Utiger R . Smoking and other lifestyle factors and the risk of Graves' hyperthyroidism. Arch Intern Med. 2005; 165(14):1606-11. DOI: 10.1001/archinte.165.14.1606. View

Paunkovic N, Paunkovic J, PAVLOVIC O, Paunovic Z . The significant increase in incidence of Graves' disease in eastern Serbia during the civil war in the former Yugoslavia (1992 to 1995). Thyroid. 1998; 8(1):37-41. DOI: 10.1089/thy.1998.8.37. View

Knudsen N, Jorgensen T, Rasmussen S, Christiansen E, Perrild H . The prevalence of thyroid dysfunction in a population with borderline iodine deficiency. Clin Endocrinol (Oxf). 1999; 51(3):361-7. DOI: 10.1046/j.1365-2265.1999.00816.x. View

Amino N, Mori H, Iwatani Y, Kawashima M, Miyai K . Significance of thyroid microsomal antibodies. Lancet. 1980; 2(8208-8209):1369. DOI: 10.1016/s0140-6736(80)92431-9. View

Bulow Pedersen I, Laurberg P, Knudsen N, Jorgensen T, Perrild H, Ovesen L . An increased incidence of overt hypothyroidism after iodine fortification of salt in Denmark: a prospective population study. J Clin Endocrinol Metab. 2007; 92(8):3122-7. DOI: 10.1210/jc.2007-0732. View

Cerqueira C, Knudsen N, Ovesen L, Laurberg P, Perrild H, Rasmussen L . Doubling in the use of thyroid hormone replacement therapy in Denmark: association to iodization of salt?. Eur J Epidemiol. 2011; 26(8):629-35. DOI: 10.1007/s10654-011-9590-5. View

Bjoro T, Holmen J, Kruger O, Midthjell K, Hunstad K, Schreiner T . Prevalence of thyroid disease, thyroid dysfunction and thyroid peroxidase antibodies in a large, unselected population. The Health Study of Nord-Trondelag (HUNT). Eur J Endocrinol. 2000; 143(5):639-47. DOI: 10.1530/eje.0.1430639. View

Vanderpump M, Tunbridge W, French J, Appleton D, Bates D, Clark F . The incidence of thyroid disorders in the community: a twenty-year follow-up of the Whickham Survey. Clin Endocrinol (Oxf). 1995; 43(1):55-68. DOI: 10.1111/j.1365-2265.1995.tb01894.x. View

10.

Berglund J, Ericsson U, Hallengren B . Increased incidence of thyrotoxicosis in Malmö during the years 1988-1990 as compared to the years 1970-1974. J Intern Med. 1996; 239(1):57-62. DOI: 10.1046/j.1365-2796.1996.415757000.x. View

11.

Prentice L, Phillips D, Sarsero D, Beever K, McLachlan S, Smith B . Geographical distribution of subclinical autoimmune thyroid disease in Britain: a study using highly sensitive direct assays for autoantibodies to thyroglobulin and thyroid peroxidase. Acta Endocrinol (Copenh). 1990; 123(5):493-8. DOI: 10.1530/acta.0.1230493. View

12.

Zaletel K, Gaberscek S, Pirnat E . Ten-year follow-up of thyroid epidemiology in Slovenia after increase in salt iodization. Croat Med J. 2011; 52(5):615-21. PMC: 3195970. DOI: 10.3325/cmj.2011.52.615. View

13.

Lantz M, Abraham-Nordling M, Svensson J, Wallin G, Hallengren B . Immigration and the incidence of Graves' thyrotoxicosis, thyrotoxic multinodular goiter and solitary toxic adenoma. Eur J Endocrinol. 2008; 160(2):201-6. DOI: 10.1530/EJE-08-0548. View

14.

Barbato M, Agar N, Kirk R . Thyroid autoantibodies in aborigines. Med J Aust. 1980; 1(11):543-5. DOI: 10.5694/j.1326-5377.1980.tb135104.x. View

15.

Pang T, Yap S, Ngan A, Bosco J . Prevalence of thyroid autoantibodies in an Asian population. Singapore Med J. 1980; 21(1):483-6. View

16.

Winsa B, Adami H, Bergstrom R, Gamstedt A, Dahlberg P, Adamson U . Stressful life events and Graves' disease. Lancet. 1991; 338(8781):1475-9. DOI: 10.1016/0140-6736(91)92298-g. View

17.

Abraham-Nordling M, Torring O, Lantz M, Hallengren B, Ohrling H, Lundell G . Incidence of hyperthyroidism in Stockholm, Sweden, 2003-2005. Eur J Endocrinol. 2008; 158(6):823-7. DOI: 10.1530/EJE-07-0877. View

18.

Belin R, Astor B, Powe N, Ladenson P . Smoke exposure is associated with a lower prevalence of serum thyroid autoantibodies and thyrotropin concentration elevation and a higher prevalence of mild thyrotropin concentration suppression in the third National Health and Nutrition Examination.... J Clin Endocrinol Metab. 2004; 89(12):6077-86. DOI: 10.1210/jc.2004-0431. View

19.

Mazziotti G, Premawardhana L, Parkes A, Adams H, Smyth P, Smith D . Evolution of thyroid autoimmunity during iodine prophylaxis--the Sri Lankan experience. Eur J Endocrinol. 2003; 149(2):103-10. DOI: 10.1530/eje.0.1490103. View

20.

Petersen K, Lindstedt G, Lundberg P, Bengtsson C, Lapidus L, Nystrom E . Thyroid disease in middle-aged and elderly Swedish women: thyroid-related hormones, thyroid dysfunction and goitre in relation to age and smoking. J Intern Med. 1991; 229(5):407-13. DOI: 10.1111/j.1365-2796.1991.tb00367.x. View