Correlation Between Oral Lichen Planus and Thyroid Disease in China: A Case-Control Study

Overview

Journal Front Endocrinol (Lausanne)

Specialty Endocrinology

Date 2018 Jul 4

PMID 29967591

Citations 11

Authors

Tingting Zhou

Dan Li

Qianming Chen

Hong Hua

Chunlei Li

Affiliations

Soon will be listed here.

Abstract

Background: A possible relationship between oral lichen planus (OLP) and thyroid disease has received attention in recent years.

Objective: This study aimed to evaluate the correlation between OLP and thyroid diseases in Chinese ethnic patients.

Methods: 192 OLP patients, 123 patients with oral lichenoid lesions (OLLs), and 162 controls were recruited in this case-control study. All participants received screening for thyroid function and underwent ultrasound. Sex and age of the patients in the three groups were matched. The prevalence of thyroid diseases in the subjects was analyzed. Using logistic regression, the odds ratio (OR) with 95% confidence intervals was appraised for associations between OLP, OLL, and different types of thyroid diseases [Hashimoto's thyroiditis (HT), hypothyroidism, and thyroid nodule].

Results: The prevalence of thyroid diseases in the OLP group (72.4%) and OLL group (68.3%) was higher than the control group (49.4%) with statistical significance. The OR of HT was 3.16 (1.87-5.33) for OLP, 2.09 (1.18-3.70) for OLL, while the OR of thyroid nodule was 2.31 (1.30-4.09) for OLP.

Conclusion: Our study suggested a close relationship between OLP/OLL and HT and thyroid nodule in a Chinese population. The possible mechanism behind this association warrants further investigation.

Citing Articles

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Crossroads between Skin and Endocrine Glands: The Interplay of Lichen Planus with Thyroid Anomalies.

Radu A, Carsote M, Nistor C, Dumitrascu M, Sandru F Biomedicines. 2024; 12(1).

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The Correlation between Oral Lichen Planus and Thyroid Pathologies: A Retrospective Study in a Sample of Italian Population.

Piloni S, Ferragina F, Barca I, Kallaverja E, Cristofaro M Eur J Dent. 2023; 18(2):510-516.

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Risk of Oral Squamous Cell Carcinoma in One Hundred Patients with Oral Lichen Planus: A Follow-Up Study of Umberto I University Hospital of Rome.

Tenore G, Mohsen A, Rocchetti F, Rossi G, Cassoni A, Battisti A Cancers (Basel). 2023; 15(11).

PMID: 37296965 PMC: 10251817. DOI: 10.3390/cancers15113004.

Risk of Prediabetes and Diabetes in Oral Lichen Planus: A Case-Control Study according to Current Diagnostic Criteria.

Rodriguez-Fonseca L, Llorente-Pendas S, Garcia-Pola M Diagnostics (Basel). 2023; 13(9).

PMID: 37174976 PMC: 10178478. DOI: 10.3390/diagnostics13091586.

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