Non-Coding RNAs As Potential Targets for Diagnosis and Treatment of Oral Lichen Planus: A Narrative Review

Overview

Journal Biomolecules

Publisher MDPI

Specialties Biochemistry
Molecular Biology

Date 2023 Nov 25

PMID 38002328

Authors

Tae-Jun Kim

Yu Gyung Kim

Won Jung

Sungil Jang

Hyoung-Gon Ko

Chan Ho Park

Jin-Seok Byun

Do-Yeon Kim

Affiliations

Soon will be listed here.

Abstract

Oral lichen planus (OLP) is a chronic inflammatory disease that is characterized by the infiltration of T cells into the oral mucosa, causing the apoptosis of basal keratinocytes. OLP is a multifactorial disease of unknown etiology and is not solely caused by the malfunction of a single key gene but rather by various intracellular and extracellular factors. Non-coding RNAs play a critical role in immunological homeostasis and inflammatory response and are found in all cell types and bodily fluids, and their expression is closely regulated to preserve normal physiologies. The dysregulation of non-coding RNAs may be highly implicated in the onset and progression of diverse inflammatory disorders, including OLP. This narrative review summarizes the role of non-coding RNAs in molecular and cellular changes in the oral epithelium during OLP pathogenesis.

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