» Articles » PMID: 28993808

MicroRNAs: New Players in the Pathobiology of Preeclampsia

Overview
Date 2017 Oct 11
PMID 28993808
Citations 40
Authors
Affiliations
Soon will be listed here.
Abstract

Our understanding of how microRNAs (miRNAs) regulate gene networks and affect different molecular pathways leading to various human pathologies has significantly improved over the years. In contrary, the role of miRNAs in pregnancy-related hypertensive disorders such as preeclampsia (PE) is only beginning to emerge. Recent papers highlight that adverse pregnancy outcomes are associated with aberrant expression of several miRNAs. Presently, efforts are underway to determine the biologic function of these placental miRNAs which can shed light on their contribution to these pregnancy-related disease conditions. The discovery that miRNAs are stable in circulation coupled with the fact that the placenta is capable of releasing them to the circulation in exosomes generates a lot of enthusiasm to use them as biomarkers. In this review, we will summarize the recent findings of our understanding of miRNA regulation in relation to PE, a hypertensive disorder of pregnancy. Particular emphasis will be given to the role of key miRNA molecules such as miR-210 and miR-155 that are known to be consistently dysregulated in women with PE.

Citing Articles

Exploring the Role of miRNA-101a in the Circulatory System's Adaptive Mechanisms in Hypertensive Disorders of Pregnancy.

Szczerba E, Kozyra-Pydys E, Zajkowska A, Pankiewicz K, Szewczyk G, Maciejewski T Diagnostics (Basel). 2025; 15(5).

PMID: 40075783 PMC: 11899601. DOI: 10.3390/diagnostics15050535.


Lateral Flow Assay for Preeclampsia Screening Using DNA Hairpins and Surface-Enhanced Raman-Active Nanoprobes Targeting hsa-miR-17-5p.

Ng K, Jaitpal S, Vu N, San Juan A, Tripathy S, Kodam R Biosensors (Basel). 2024; 14(11).

PMID: 39589994 PMC: 11592307. DOI: 10.3390/bios14110535.


A Narrative Review on the Pathophysiology of Preeclampsia.

Torres-Torres J, Espino-Y-Sosa S, Martinez-Portilla R, Borboa-Olivares H, Estrada-Gutierrez G, Acevedo-Gallegos S Int J Mol Sci. 2024; 25(14).

PMID: 39062815 PMC: 11277207. DOI: 10.3390/ijms25147569.


DNA methylation landscape in pregnancy-induced hypertension: progress and challenges.

Deng F, Lei J, Qiu J, Zhao C, Wang X, Li M Reprod Biol Endocrinol. 2024; 22(1):77.

PMID: 38978060 PMC: 11229300. DOI: 10.1186/s12958-024-01248-0.


Epigenetic alterations in preeclampsia: a focus on microRNA149 and tetrahydrofolate reductase gene polymorphisms in Egyptian women.

Ellakwa D, Rashed L, El-Mandoury A, Younis N Ir J Med Sci. 2024; 193(5):2363-2374.

PMID: 38848035 DOI: 10.1007/s11845-024-03732-3.


References
1.
Veit T, Chies J . Tolerance versus immune response -- microRNAs as important elements in the regulation of the HLA-G gene expression. Transpl Immunol. 2008; 20(4):229-31. DOI: 10.1016/j.trim.2008.11.001. View

2.
Zhu X, Han T, Sargent I, Yin G, Yao Y . Differential expression profile of microRNAs in human placentas from preeclamptic pregnancies vs normal pregnancies. Am J Obstet Gynecol. 2009; 200(6):661.e1-7. DOI: 10.1016/j.ajog.2008.12.045. View

3.
Burke S, Karumanchi S . Spiral artery remodeling in preeclampsia revisited. Hypertension. 2013; 62(6):1013-4. DOI: 10.1161/HYPERTENSIONAHA.113.02049. View

4.
Bernstein E, Kim S, Carmell M, Murchison E, Alcorn H, Li M . Dicer is essential for mouse development. Nat Genet. 2003; 35(3):215-7. DOI: 10.1038/ng1253. View

5.
Lee D, Romero R, Kim J, Tarca A, Montenegro D, Pineles B . miR-210 targets iron-sulfur cluster scaffold homologue in human trophoblast cell lines: siderosis of interstitial trophoblasts as a novel pathology of preterm preeclampsia and small-for-gestational-age pregnancies. Am J Pathol. 2011; 179(2):590-602. PMC: 3160082. DOI: 10.1016/j.ajpath.2011.04.035. View