The Role of MiRNA-210 in Pre-eclampsia Development

Overview

Journal Ann Med

Publisher Informa Healthcare

Specialty General Medicine

Date 2022 May 11

PMID 35543206

Authors

Ilona Jaszczuk

Dorota Koczkodaj

Adrianna Kondracka

Anna Kwasniewska

Izabela Winkler

Agata Filip

Affiliations

Soon will be listed here.

Abstract

MicroRNAs (miRNAs) are a class of small non-coding, single-stranded RNAs (ribonucleic acids) that play important roles in many vital processes through their impact on gene expression. One such miRNA, miR210, represents a hypoxia-induced cellular miRNA group that hold a variety of functions. This review article highlights the importance of miR-210 in the development of pre-eclampsia.KEY MESSAGEmiR-210 is a promising biomarker for monitoring pregnancy with pre-eclampsia. Overexpression of miR-210 had a negative impact on the process of cell migration and trophoblast invasion.

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References

Turco M, Gardner L, Kay R, Hamilton R, Prater M, Hollinshead M . Trophoblast organoids as a model for maternal-fetal interactions during human placentation. Nature. 2018; 564(7735):263-267. PMC: 7220805. DOI: 10.1038/s41586-018-0753-3. View

Mihu D, Razvan C, Malutan A, Mihaela C . Evaluation of maternal systemic inflammatory response in preeclampsia. Taiwan J Obstet Gynecol. 2015; 54(2):160-6. DOI: 10.1016/j.tjog.2014.03.006. View

Wojczakowski W, Kimber-Trojnar Z, Dziwisz F, Slodzinska M, Slodzinski H, Leszczynska-Gorzelak B . Preeclampsia and Cardiovascular Risk for Offspring. J Clin Med. 2021; 10(14). PMC: 8306208. DOI: 10.3390/jcm10143154. View

Wang H, Zhao Y, Luo R, Bian X, Wang Y, Shao X . A positive feedback self-regulatory loop between miR-210 and HIF-1α mediated by CPEB2 is involved in trophoblast syncytialization: implication of trophoblast malfunction in preeclampsia†. Biol Reprod. 2019; 102(3):560-570. DOI: 10.1093/biolre/ioz196. View

Koushki M, Amiri Dash Atan N, Omidi-Ardali H, Rezaei Tavirani M . Assessment of Correlation Between miR-210 Expression and Pre-Eclampsia Risk: A Meta-Analysis. Rep Biochem Mol Biol. 2018; 7(1):94-101. PMC: 6175589. View

Slezak-Prochazka I, Durmus S, Kroesen B, van den Berg A . MicroRNAs, macrocontrol: regulation of miRNA processing. RNA. 2010; 16(6):1087-95. PMC: 2874160. DOI: 10.1261/rna.1804410. View

Awamleh Z, Han V . Identification of miR-210-5p in human placentae from pregnancies complicated by preeclampsia and intrauterine growth restriction, and its potential role in the pregnancy complications. Pregnancy Hypertens. 2020; 19:159-168. DOI: 10.1016/j.preghy.2020.01.002. View

Luo R, Shao X, Xu P, Liu Y, Wang Y, Zhao Y . MicroRNA-210 contributes to preeclampsia by downregulating potassium channel modulatory factor 1. Hypertension. 2014; 64(4):839-45. DOI: 10.1161/HYPERTENSIONAHA.114.03530. View

Leavey K, Benton S, Grynspan D, Kingdom J, Bainbridge S, Cox B . Unsupervised Placental Gene Expression Profiling Identifies Clinically Relevant Subclasses of Human Preeclampsia. Hypertension. 2016; 68(1):137-47. DOI: 10.1161/HYPERTENSIONAHA.116.07293. View

10.

Fu G, Brkic J, Hayder H, Peng C . MicroRNAs in Human Placental Development and Pregnancy Complications. Int J Mol Sci. 2013; 14(3):5519-44. PMC: 3634453. DOI: 10.3390/ijms14035519. View

11.

Sekizawa A, Jimbo M, Saito H, Iwasaki M, Matsuoka R, Okai T . Cell-free fetal DNA in the plasma of pregnant women with severe fetal growth restriction. Am J Obstet Gynecol. 2003; 188(2):480-4. DOI: 10.1067/mob.2003.27. View

12.

Goswami D, Tannetta D, Magee L, Fuchisawa A, Redman C, Sargent I . Excess syncytiotrophoblast microparticle shedding is a feature of early-onset pre-eclampsia, but not normotensive intrauterine growth restriction. Placenta. 2005; 27(1):56-61. DOI: 10.1016/j.placenta.2004.11.007. View

13.

Hromadnikova I, Kotlabova K, Doucha J, Dlouha K, Krofta L . Absolute and relative quantification of placenta-specific micrornas in maternal circulation with placental insufficiency-related complications. J Mol Diagn. 2012; 14(2):160-7. DOI: 10.1016/j.jmoldx.2011.11.003. View

14.

Zhao G, Zhou X, Chen S, Miao H, Fan H, Wang Z . Differential expression of microRNAs in decidua-derived mesenchymal stem cells from patients with pre-eclampsia. J Biomed Sci. 2014; 21:81. PMC: 4237795. DOI: 10.1186/s12929-014-0081-3. View

15.

Nakayama K . Cellular signal transduction of the hypoxia response. J Biochem. 2009; 146(6):757-65. DOI: 10.1093/jb/mvp167. View

16.

Anton L, DeVine A, Polyak E, Olarerin-George A, Brown A, Falk M . HIF-1α Stabilization Increases miR-210 Eliciting First Trimester Extravillous Trophoblast Mitochondrial Dysfunction. Front Physiol. 2019; 10:699. PMC: 6590495. DOI: 10.3389/fphys.2019.00699. View

17.

Vento-Tormo R, Efremova M, Botting R, Turco M, Vento-Tormo M, Meyer K . Single-cell reconstruction of the early maternal-fetal interface in humans. Nature. 2018; 563(7731):347-353. PMC: 7612850. DOI: 10.1038/s41586-018-0698-6. View

18.

Gilad S, Meiri E, Yogev Y, Benjamin S, Lebanony D, Yerushalmi N . Serum microRNAs are promising novel biomarkers. PLoS One. 2008; 3(9):e3148. PMC: 2519789. DOI: 10.1371/journal.pone.0003148. View

19.

Lecarpentier E, Tsatsaris V . Angiogenic balance (sFlt-1/PlGF) and preeclampsia. Ann Endocrinol (Paris). 2016; 77(2):97-100. DOI: 10.1016/j.ando.2016.04.007. View

20.

Burton G, Watson A, Hempstock J, Skepper J, Jauniaux E . Uterine glands provide histiotrophic nutrition for the human fetus during the first trimester of pregnancy. J Clin Endocrinol Metab. 2002; 87(6):2954-9. DOI: 10.1210/jcem.87.6.8563. View