DNA Methylation Landscape in Pregnancy-induced hypertension: Progress and Challenges

Overview

Journal Reprod Biol Endocrinol

Publisher Biomed Central

Specialties Endocrinology
Reproductive Medicine

Date 2024 Jul 8

PMID 38978060

Authors

Fengying Deng

Jiahui Lei

Junlan Qiu

Chenxuan Zhao

Xietong Wang

Min Li

Miao Sun

Meihua Zhang

Qinqin Gao

Affiliations

Soon will be listed here.

Abstract

Gestational hypertension (PIH), especially pre-eclampsia (PE), is a common complication of pregnancy. This condition poses significant risks to the health of both the mother and the fetus. Emerging evidence suggests that epigenetic modifications, particularly DNA methylation, may play a role in initiating the earliest pathophysiology of PIH. This article describes the relationship between DNA methylation and placental trophoblast function, genes associated with the placental microenvironment, the placental vascular system, and maternal blood and vascular function, abnormalities of umbilical cord blood and vascular function in the onset and progression of PIH, as well as changes in DNA methylation in the progeny of PIH, in terms of maternal, fetal, and offspring. We also explore the latest research on DNA methylation-based early detection, diagnosis and potential therapeutic strategies for PIH. This will enable the field of DNA methylation research to continue to enhance our understanding of the epigenetic regulation of PIH genes and identify potential therapeutic targets.

Citing Articles

From Pregnancy to Breastfeeding: The Role of Maternal Exercise in Preventing Childhood Obesity.

Calcaterra V, Cena H, Pirazzi A, Sottotetti F, Cordaro E, Cavallo C Nutrients. 2025; 17(4).

PMID: 40004988 PMC: 11858060. DOI: 10.3390/nu17040660.

Correction: DNA methylation landscape in pregnancyinduced hypertension: progress and challenges.

Deng F, Lei J, Qiu J, Zhao C, Wang X, Li M Reprod Biol Endocrinol. 2024; 22(1):99.

PMID: 39113076 PMC: 11304555. DOI: 10.1186/s12958-024-01270-2.

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