Long Non-coding RNA SPRY4-IT1 Promotes Gallbladder Carcinoma Progression

Overview

Journal Oncotarget

Specialty Oncology

Date 2016 Dec 1

PMID 27902971

Citations 11

Authors

Liang Yang

Xi Cheng

Naijian Ge

Weixing Guo

Feiling Feng

Fuying Wan

Affiliations

Soon will be listed here.

Abstract

Gallbladder carcinoma (GBC) is the most common malignancy of the bile duct and patients with GBC have extremely poor prognoses. Long non-coding RNAs (lncRNAs) are found to be dysregulated in a variety of cancers, including GBC. SPRY4-IT1 has been recently revealed as oncogenic regulator in many cancers. However, whether SPRY4-IT1 is involved in GBC progression remains largely unknown. To investigate the role of SPRY4-IT1 in GBC, we evaluated the expression SPRY4-IT1 in GBC tissues and cell lines, and investigated the effect of SPRY4-IT1 knockdown on cell proliferation, migration and invasion of GBC in vitro. Our result showed that SPRY4-IT1 was upregulated in GBC tissues. Further experiments revealed that SPRY4-IT1 knockdown significantly inhibited GBC cell proliferation. Furthermore, inhibitory effects of SPRY4-IT1 on cell migration and invasion were partly associated with EMT process. In conclusion, these data suggest that SPRY4-IT1 could be an oncogene for GBC, and may be served as a candidate target for new therapies in human GBC.

Citing Articles

Natural products and long noncoding RNA signatures in gallbladder cancer: a review focuses on pathogenesis, diagnosis, and drug resistance.

Elimam H, Alhamshry N, Hatawsh A, Elfar N, Moussa R, Radwan A Naunyn Schmiedebergs Arch Pharmacol. 2024; 397(12):9549-9571.

PMID: 39028332 DOI: 10.1007/s00210-024-03279-1.

Non-coding RNAs as potential biomarkers of gallbladder cancer.

Lv Y, Yin W, Zhang Z Clin Transl Oncol. 2022; 25(6):1489-1511.

PMID: 36576705 DOI: 10.1007/s12094-022-03056-7.

A Review on the Role of SPRY4-IT1 in the Carcinogenesis.

Ghafouri-Fard S, Khoshbakht T, Taheri M, Shojaei S Front Oncol. 2022; 11:779483.

PMID: 35096580 PMC: 8792834. DOI: 10.3389/fonc.2021.779483.

Reiterating the Emergence of Noncoding RNAs as Regulators of the Critical Hallmarks of Gall Bladder Cancer.

Rana V, Parama D, Khatoon E, Girisa S, Sethi G, Kunnumakkara A Biomolecules. 2021; 11(12).

PMID: 34944491 PMC: 8699045. DOI: 10.3390/biom11121847.

Long non-coding RNA TMPO-AS1 promotes cell proliferation, migration, invasion and epithelial-to-mesenchymal transition in gallbladder carcinoma by regulating the microRNA-1179/E2F2 axis.

Sui Z, Sui X Oncol Lett. 2021; 22(6):855.

PMID: 34777589 PMC: 8581476. DOI: 10.3892/ol.2021.13116.

References

Batista P, Chang H . Long noncoding RNAs: cellular address codes in development and disease. Cell. 2013; 152(6):1298-307. PMC: 3651923. DOI: 10.1016/j.cell.2013.02.012. View

Butte J, Matsuo K, Gonen M, DAngelica M, Waugh E, Allen P . Gallbladder cancer: differences in presentation, surgical treatment, and survival in patients treated at centers in three countries. J Am Coll Surg. 2010; 212(1):50-61. DOI: 10.1016/j.jamcollsurg.2010.09.009. View

Khaitan D, Dinger M, Mazar J, Crawford J, Smith M, Mattick J . The melanoma-upregulated long noncoding RNA SPRY4-IT1 modulates apoptosis and invasion. Cancer Res. 2011; 71(11):3852-62. DOI: 10.1158/0008-5472.CAN-10-4460. View

Bal M, Ramadwar M, Deodhar K, Shrikhande S . Pathology of gallbladder carcinoma: current understanding and new perspectives. Pathol Oncol Res. 2015; 21(3):509-25. DOI: 10.1007/s12253-014-9886-3. View

Thiery J, Acloque H, Huang R, Nieto M . Epithelial-mesenchymal transitions in development and disease. Cell. 2009; 139(5):871-90. DOI: 10.1016/j.cell.2009.11.007. View

Kanthan R, Senger J, Ahmed S, Kanthan S . Gallbladder Cancer in the 21st Century. J Oncol. 2015; 2015:967472. PMC: 4569807. DOI: 10.1155/2015/967472. View

Jing W, Gao S, Zhu M, Luo P, Jing X, Chai H . Potential diagnostic value of lncRNA SPRY4-IT1 in hepatocellular carcinoma. Oncol Rep. 2016; 36(2):1085-92. DOI: 10.3892/or.2016.4859. View

Gibb E, Brown C, Lam W . The functional role of long non-coding RNA in human carcinomas. Mol Cancer. 2011; 10:38. PMC: 3098824. DOI: 10.1186/1476-4598-10-38. View

Cziupka K, Partecke L, Mirow L, Heidecke C, Emde C, Hoffmann W . Outcomes and prognostic factors in gallbladder cancer: a single-centre experience. Langenbecks Arch Surg. 2012; 397(6):899-907. DOI: 10.1007/s00423-012-0950-8. View

10.

Xie H, Wu Q, Zhu B, Chen F, Ji L, Li S . Long noncoding RNA SPRY4-IT1 is upregulated in esophageal squamous cell carcinoma and associated with poor prognosis. Tumour Biol. 2014; 35(8):7743-54. DOI: 10.1007/s13277-014-2013-y. View

11.

Tekcham D, Tiwari P . Non-coding RNAs as emerging molecular targets of gallbladder cancer. Gene. 2016; 588(1):79-85. DOI: 10.1016/j.gene.2016.04.047. View

12.

Prensner J, Chinnaiyan A . The emergence of lncRNAs in cancer biology. Cancer Discov. 2011; 1(5):391-407. PMC: 3215093. DOI: 10.1158/2159-8290.CD-11-0209. View

13.

Kakaei F, Beheshtirouy S, Nejatollahi S, Zarrintan S, Mafi M . Surgical treatment of gallbladder carcinoma: a critical review. Updates Surg. 2015; 67(4):339-51. DOI: 10.1007/s13304-015-0328-x. View

14.

Fatica A, Bozzoni I . Long non-coding RNAs: new players in cell differentiation and development. Nat Rev Genet. 2013; 15(1):7-21. DOI: 10.1038/nrg3606. View

15.

Zhang H, Yang F, Yan Y, Che J, Zheng J . High expression of long non-coding RNA SPRY4-IT1 predicts poor prognosis of clear cell renal cell carcinoma. Int J Clin Exp Pathol. 2014; 7(9):5801-9. PMC: 4203192. View

16.

Xie M, Nie F, Sun M, Xia R, Liu Y, Zhou P . Decreased long noncoding RNA SPRY4-IT1 contributing to gastric cancer cell metastasis partly via affecting epithelial-mesenchymal transition. J Transl Med. 2015; 13:250. PMC: 4522960. DOI: 10.1186/s12967-015-0595-9. View

17.

Mouraviev V, Lee B, Patel V, Albala D, Johansen T, Partin A . Clinical prospects of long noncoding RNAs as novel biomarkers and therapeutic targets in prostate cancer. Prostate Cancer Prostatic Dis. 2015; 19(1):14-20. DOI: 10.1038/pcan.2015.48. View

18.

Sun M, Liu X, Lu K, Nie F, Xia R, Kong R . EZH2-mediated epigenetic suppression of long noncoding RNA SPRY4-IT1 promotes NSCLC cell proliferation and metastasis by affecting the epithelial-mesenchymal transition. Cell Death Dis. 2014; 5:e1298. PMC: 4611729. DOI: 10.1038/cddis.2014.256. View

19.

Peng W, Wu G, Fan H, Wu J, Feng J . Long noncoding RNA SPRY4-IT1 predicts poor patient prognosis and promotes tumorigenesis in gastric cancer. Tumour Biol. 2015; 36(9):6751-8. DOI: 10.1007/s13277-015-3376-4. View

20.

Ponting C, Oliver P, Reik W . Evolution and functions of long noncoding RNAs. Cell. 2009; 136(4):629-41. DOI: 10.1016/j.cell.2009.02.006. View