The Emergence of LncRNAs in Cancer Biology

Overview

Journal Cancer Discov

Specialty Oncology

Date 2011 Nov 19

PMID 22096659

Citations 1002

Authors

John R Prensner

Arul M Chinnaiyan

Affiliations

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Abstract

The discovery of numerous noncoding RNA (ncRNA) transcripts in species from yeast to mammals has dramatically altered our understanding of cell biology, especially the biology of diseases such as cancer. In humans, the identification of abundant long ncRNA (lncRNA) >200 bp has catalyzed their characterization as critical components of cancer biology. Recently, roles for lncRNAs as drivers of tumor suppressive and oncogenic functions have appeared in prevalent cancer types, such as breast and prostate cancer. In this review, we highlight the emerging impact of ncRNAs in cancer research, with a particular focus on the mechanisms and functions of lncRNAs.

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