Long Noncoding RNAs: Cellular Address Codes in Development and Disease

Overview

Journal Cell

Publisher Cell Press

Specialty Cell Biology

Date 2013 Mar 19

PMID 23498938

Citations 1459

Authors

Pedro J Batista

Howard Y Chang

Affiliations

Soon will be listed here.

Abstract

In biology as in real estate, location is a cardinal organizational principle that dictates the accessibility and flow of informational traffic. An essential question in nuclear organization is the nature of the address code--how objects are placed and later searched for and retrieved. Long noncoding RNAs (lncRNAs) have emerged as key components of the address code, allowing protein complexes, genes, and chromosomes to be trafficked to appropriate locations and subject to proper activation and deactivation. lncRNA-based mechanisms control cell fates during development, and their dysregulation underlies some human disorders caused by chromosomal deletions and translocations.

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