The Past, Present and Future of Ligament Regenerative Engineering

Overview

Journal Regen Med

Specialty Biotechnology

Date 2016 Nov 24

PMID 27879170

Citations 13

Authors

Paulos Y Mengsteab

Lakshmi S Nair

Cato T Laurencin

Affiliations

Soon will be listed here.

Abstract

Regenerative engineering has been defined as the convergence of Advanced Materials Sciences, Stem Cell Sciences, Physics, Developmental Biology and Clinical Translation for the regeneration of complex tissues and organ systems. Anterior cruciate ligament (ACL) reconstruction necessitates the regeneration of bone, ligament and their interface to achieve superior clinical results. In the past, the ACL has been repaired with the use of autologous and allogeneic grafts, which have their respective drawbacks. Currently, investigations on the use of biodegradable matrices to achieve knee stability and permit tissue regeneration are making promising advancements. In the future, utilizing regenerative biology cues to induce an endogenous regenerative response may aid the enhancement of clinical ACL reconstruction outcomes.

Citing Articles

[Research progress on early postoperative pain management strategies after arthroscopic anterior cruciate ligament reconstruction].

Yu H, Shi Z, Xiong B, Li Y, Qin Y, Dong K Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2024; 38(2):218-225.

PMID: 38385236 PMC: 10882226. DOI: 10.7507/1002-1892.202311105.

[Research progress on bioactive strategies for promoting tendon graft healing after anterior cruciate ligament reconstruction].

Cai W, Li J, Li Q Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2023; 37(10):1292-1299.

PMID: 37848327 PMC: 10581880. DOI: 10.7507/1002-1892.202306088.

Bioactive Nanostructured Scaffold-Based Approach for Tendon and Ligament Tissue Engineering.

Govindaraju D, Chen C, Shalumon K, Kao H, Chen J Nanomaterials (Basel). 2023; 13(12).

PMID: 37368277 PMC: 10302175. DOI: 10.3390/nano13121847.

Advanced Gene Therapy Strategies for the Repair of ACL Injuries.

Amini M, Venkatesan J, Liu W, Leroux A, Nguyen T, Madry H Int J Mol Sci. 2022; 23(22).

PMID: 36430947 PMC: 9695211. DOI: 10.3390/ijms232214467.

Nanofiber Scaffold Based on Polylactic Acid-Polycaprolactone for Anterior Cruciate Ligament Injury.

Aminatun , Huriah R, Hikmawati D, Hadi S, Amrillah T, Abdullah C Polymers (Basel). 2022; 14(15).

PMID: 35893947 PMC: 9331771. DOI: 10.3390/polym14152983.

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