Bio-enhanced Repair of the Anterior Cruciate Ligament

Overview

Journal Arthroscopy

Specialty Orthopedics

Date 2015 Jan 18

PMID 25595694

Citations 18

Authors

Benedikt L Proffen

Jakob T Sieker

Martha M Murray

Affiliations

Soon will be listed here.

Abstract

Suture repair of the anterior cruciate ligament (ACL) has been widely abandoned in favor of ACL reconstruction, largely because of the high rates of failure and unreliability of the outcomes after suture repair. However, there have been recent basic science studies that suggest that combining a suture repair with a biological adjunct may improve the results of suture repair of the ACL, with several studies in large animal models showing equivalent strength of an ACL treated with bio-enhanced repaired to that of an ACL graft at 3, 6, and 12 months after surgery. In addition, the groups treated with bio-enhanced repair had significantly less osteoarthritis when compared with the animals undergoing ACL reconstruction. These findings have led to a renewed interest in bio-enhanced primary repair as a way to make repair of the ACL a viable option for a select group of patients in the future.

Citing Articles

Advanced Graft Development Approaches for ACL Reconstruction or Regeneration.

Urbanek O, Moczulska-Heljak M, Wrobel M, Mioduszewski A, Kolbuk D Biomedicines. 2023; 11(2).

PMID: 36831043 PMC: 9953332. DOI: 10.3390/biomedicines11020507.

Efficacy of Repair for ACL Injury: A Meta‑analysis of Randomized Controlled Trials.

Li Z Int J Sports Med. 2022; 43(13):1071-1083.

PMID: 35100655 PMC: 9713465. DOI: 10.1055/a-1755-4925.

[Effectiveness of partial anterior cruciate ligament suture repair with wide awake local anesthesia no tourniquet technique].

Wei Y, Yun X, Liu Y, Wei M Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2021; 35(3):337-342.

PMID: 33719243 PMC: 8171753. DOI: 10.7507/1002-1892.202008127.

ACL Repair: A Game Changer or Will History Repeat Itself? A Critical Appraisal.

Heusdens C J Clin Med. 2021; 10(5).

PMID: 33652689 PMC: 7956607. DOI: 10.3390/jcm10050912.

Is Primary Arthroscopic Repair Using the Pulley Technique an Effective Treatment for Partial Proximal ACL Tears?.

Liao W, Zhang Q Clin Orthop Relat Res. 2019; 478(5):1031-1045.

PMID: 31876551 PMC: 7170704. DOI: 10.1097/CORR.0000000000001118.

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