Biodegradable Polymer Nanocomposites for Ligament/tendon Tissue Engineering

Overview

Journal J Nanobiotechnology

Publisher Biomed Central

Specialty Biotechnology

Date 2020 Feb 1

PMID 32000800

Citations 44

Authors

Magda Silva

Fernando N Ferreira

Natalia M Alves

Maria C Paiva

Affiliations

Soon will be listed here.

Abstract

Ligaments and tendons are fibrous tissues with poor vascularity and limited regeneration capacity. Currently, a ligament/tendon injury often require a surgical procedure using auto- or allografts that present some limitations. These inadequacies combined with the significant economic and health impact have prompted the development of tissue engineering approaches. Several natural and synthetic biodegradable polymers as well as composites, blends and hybrids based on such materials have been used to produce tendon and ligament scaffolds. Given the complex structure of native tissues, the production of fiber-based scaffolds has been the preferred option for tendon/ligament tissue engineering. Electrospinning and several textile methods such as twisting, braiding and knitting have been used to produce these scaffolds. This review focuses on the developments achieved in the preparation of tendon/ligament scaffolds based on different biodegradable polymers. Several examples are overviewed and their processing methodologies, as well as their biological and mechanical performances, are discussed.

Citing Articles

Integrating Modern Technologies into Traditional Anterior Cruciate Ligament Tissue Engineering.

Sopilidis A, Stamatopoulos V, Giannatos V, Taraviras G, Panagopoulos A, Taraviras S Bioengineering (Basel). 2025; 12(1).

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Advancing Adult-Acquired Flatfoot Deformity Treatment: Enhanced Biomechanical Support Through Graphene Oxide-Integrated Bioengineered Grafts Tested In Silico.

Nieto S, Gantiva-Diaz M, Hoyos M, Montoya Y, Cruz J, Cifuentes-De la Portilla C J Funct Biomater. 2024; 15(11).

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Mechanical, Biological and In Vitro Degradation Investigation of Braided Scaffolds for Tendon and Ligament Tissue Engineering Based on Different Polycaprolactone Materials with Chitosan-Graft-PCL Surface Modification.

Emonts C, Bauer B, Pitts J, Roger Y, Hoffmann A, Menzel H Polymers (Basel). 2024; 16(16).

PMID: 39204570 PMC: 11360056. DOI: 10.3390/polym16162349.

(Bio)degradable Biochar Composites of PLA/P(3HB--4HB) Commercial Blend for Sustainable Future-Study on Degradation and Electrostatic Properties.

Musiol M, Rydz J, Janeczek H, Andrzejewski J, Cristea M, Musiol K Polymers (Basel). 2024; 16(16).

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PLCL/SF/NGF nerve conduit loaded with RGD-TA-PPY hydrogel promotes regeneration of sciatic nerve defects in rats through PI3K/AKT signalling pathways.

Liu K, Tang W, Jin S, Hao X, Hu Y, Zhou T J Cell Mol Med. 2024; 28(15):e18544.

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