Phase-stable Swept Source OCT Angiography in Human Skin Using an Akinetic Source

Overview

Journal Biomed Opt Express

Specialty Radiology

Date 2016 Aug 30

PMID 27570695

Citations 32

Authors

Zhe Chen

Mengyang Liu

Michael Minneman

Laurin Ginner

Erich Hoover

Harald Sattmann

Marco Bonesi

Wolfgang Drexler

Rainer A Leitgeb

Affiliations

Soon will be listed here.

Abstract

We demonstrate noninvasive structural and microvascular contrast imaging of human skin in vivo, using phase difference swept source OCT angiography (pOCTA). The pOCTA system employs an akinetic, all-semiconductor, highly phase-stable swept laser source which operates at 1340 nm central wavelength, with 37 nm bandwidth (at 0 dB region) and 200 kHz A-scan rate. The phase sensitive detection does not need any external phase stabilizing implementations, due to the outstanding high phase linearity and sweep phase repeatability within 2 mrad. We compare the performance of phase based OCTA to speckle based OCTA for visualizing human vascular networks. pOCTA shows better contrast especially for deeper vascular details as compared to speckle based OCTA. The phase stability of the akinetic source allows the OCTA system to show decent vascular contrast only with 2 B-scans. We compare the performance of using 2 versus 4 B-scans for calculating the vascular contrast. Finally, the performance of a 100 nm bandwidth akinetic laser at 1310 nm is investigated for both OCT and OCTA.

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