Contrast-enhanced CT- and MRI-based Perfusion Assessment for Pulmonary Diseases: Basics and Clinical Applications

Overview

Journal Diagn Interv Radiol

Publisher Galenos Publishing House

Date 2016 Aug 16

PMID 27523813

Citations 13

Authors

Yoshiharu Ohno

Hisanobu Koyama

Ho Yun Lee

Sachiko Miura

Takeshi Yoshikawa

Kazuro Sugimura

Affiliations

Soon will be listed here.

Abstract

Assessment of regional pulmonary perfusion as well as nodule and tumor perfusions in various pulmonary diseases are currently performed by means of nuclear medicine studies requiring radioactive macroaggregates, dual-energy computed tomography (CT), and dynamic first-pass contrast-enhanced perfusion CT techniques and unenhanced and dynamic first-pass contrast enhanced perfusion magnetic resonance imaging (MRI), as well as time-resolved three-dimensional or four-dimensional contrast-enhanced magnetic resonance angiography (MRA). Perfusion scintigraphy, single-photon emission tomography (SPECT) and SPECT fused with CT have been established as clinically available scintigraphic methods; however, they are limited by perfusion information with poor spatial resolution and other shortcomings. Although positron emission tomography with 15O water can measure absolute pulmonary perfusion, it requires a cyclotron for generation of a tracer with an extremely short half-life (2 min), and can only be performed for academic purposes. Therefore, clinicians are concentrating their efforts on the application of CT-based and MRI-based quantitative and qualitative perfusion assessment to various pulmonary diseases. This review article covers 1) the basics of dual-energy CT and dynamic first-pass contrast-enhanced perfusion CT techniques, 2) the basics of time-resolved contrast-enhanced MRA and dynamic first-pass contrast-enhanced perfusion MRI, and 3) clinical applications of contrast-enhanced CT- and MRI-based perfusion assessment for patients with pulmonary nodule, lung cancer, and pulmonary vascular diseases. We believe that these new techniques can be useful in routine clinical practice for not only thoracic oncology patients, but also patients with different pulmonary vascular diseases.

Citing Articles

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References

Ohno Y, Koyama H, Matsumoto K, Onishi Y, Nogami M, Takenaka D . Dynamic MR perfusion imaging: capability for quantitative assessment of disease extent and prediction of outcome for patients with acute pulmonary thromboembolism. J Magn Reson Imaging. 2010; 31(5):1081-90. DOI: 10.1002/jmri.22146. View

Ohno Y . New applications of magnetic resonance imaging for thoracic oncology. Semin Respir Crit Care Med. 2014; 35(1):27-40. DOI: 10.1055/s-0033-1363449. View

Matsuoka S, Hunsaker A, Gill R, Jacobson F, Ohno Y, Patz S . Functional MR imaging of the lung. Magn Reson Imaging Clin N Am. 2008; 16(2):275-89, ix. DOI: 10.1016/j.mric.2008.03.006. View

Soler X, Kerr K, Marsh J, Renner J, Hoh C, Test V . Pilot study comparing SPECT perfusion scintigraphy with CT pulmonary angiography in chronic thromboembolic pulmonary hypertension. Respirology. 2011; 17(1):180-4. DOI: 10.1111/j.1440-1843.2011.02061.x. View

Miyazaki M, Akahane M . Non-contrast enhanced MR angiography: established techniques. J Magn Reson Imaging. 2011; 35(1):1-19. DOI: 10.1002/jmri.22789. View

Ohno Y, Koyama H, Takenaka D, Nogami M, Maniwa Y, Nishimura Y . Dynamic MRI, dynamic multidetector-row computed tomography (MDCT), and coregistered 2-[fluorine-18]-fluoro-2-deoxy-D-glucose-positron emission tomography (FDG-PET)/CT: comparative study of capability for management of pulmonary nodules. J Magn Reson Imaging. 2008; 27(6):1284-95. DOI: 10.1002/jmri.21348. View

Therasse P, Arbuck S, Eisenhauer E, Wanders J, Kaplan R, Rubinstein L . New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. J Natl Cancer Inst. 2000; 92(3):205-16. DOI: 10.1093/jnci/92.3.205. View

Uematsu H, Ohno Y, Hatabu H . Recent advances in magnetic resonance perfusion imaging of the lung. Top Magn Reson Imaging. 2003; 14(3):245-51. DOI: 10.1097/00002142-200306000-00005. View

Schuster D . ARDS: clinical lessons from the oleic acid model of acute lung injury. Am J Respir Crit Care Med. 1994; 149(1):245-60. DOI: 10.1164/ajrccm.149.1.8111590. View

10.

Ohno Y, Higashino T, Takenaka D, Sugimoto K, Yoshikawa T, Kawai H . MR angiography with sensitivity encoding (SENSE) for suspected pulmonary embolism: comparison with MDCT and ventilation-perfusion scintigraphy. AJR Am J Roentgenol. 2004; 183(1):91-8. DOI: 10.2214/ajr.183.1.1830091. View

11.

Ohno Y, Koyama H, Nogami M, Takenaka D, Matsumoto S, Onishi Y . Dynamic perfusion MRI: capability for evaluation of disease severity and progression of pulmonary arterial hypertension in patients with connective tissue disease. J Magn Reson Imaging. 2008; 28(4):887-99. DOI: 10.1002/jmri.21550. View

12.

Nikolaou K, Schoenberg S, Attenberger U, Scheidler J, Dietrich O, Kuehn B . Pulmonary arterial hypertension: diagnosis with fast perfusion MR imaging and high-spatial-resolution MR angiography--preliminary experience. Radiology. 2005; 236(2):694-703. DOI: 10.1148/radiol.2361040502. View

13.

Thieme S, Graute V, Nikolaou K, Maxien D, Reiser M, Hacker M . Dual Energy CT lung perfusion imaging--correlation with SPECT/CT. Eur J Radiol. 2010; 81(2):360-5. DOI: 10.1016/j.ejrad.2010.11.037. View

14.

Hecht E, Rosenkrantz A . Pulmonary MR angiography techniques and applications. Magn Reson Imaging Clin N Am. 2009; 17(1):101-31. DOI: 10.1016/j.mric.2009.01.001. View

15.

Herzog P, Wildberger J, Niethammer M, Schaller S, Schoepf U . CT perfusion imaging of the lung in pulmonary embolism. Acad Radiol. 2003; 10(10):1132-46. DOI: 10.1016/s1076-6332(03)00334-9. View

16.

Kaza R, Platt J, Cohan R, Caoili E, Al-Hawary M, Wasnik A . Dual-energy CT with single- and dual-source scanners: current applications in evaluating the genitourinary tract. Radiographics. 2012; 32(2):353-69. DOI: 10.1148/rg.322115065. View

17.

Ohno Y, Koyama H, Fujisawa Y, Yoshikawa T, Seki S, Sugihara N . Dynamic contrast-enhanced perfusion area detector CT for non-small cell lung cancer patients: Influence of mathematical models on early prediction capabilities for treatment response and recurrence after chemoradiotherapy. Eur J Radiol. 2016; 85(1):176-186. DOI: 10.1016/j.ejrad.2015.11.009. View

18.

Thieme S, Becker C, Hacker M, Nikolaou K, Reiser M, Johnson T . Dual energy CT for the assessment of lung perfusion--correlation to scintigraphy. Eur J Radiol. 2008; 68(3):369-74. DOI: 10.1016/j.ejrad.2008.07.031. View

19.

Geyer L, Scherr M, Korner M, Wirth S, Deak P, Reiser M . Imaging of acute pulmonary embolism using a dual energy CT system with rapid kVp switching: initial results. Eur J Radiol. 2011; 81(12):3711-8. DOI: 10.1016/j.ejrad.2011.02.043. View

20.

Sieren J, Ohno Y, Koyama H, Sugimura K, McLennan G . Recent technological and application developments in computed tomography and magnetic resonance imaging for improved pulmonary nodule detection and lung cancer staging. J Magn Reson Imaging. 2010; 32(6):1353-69. PMC: 3058763. DOI: 10.1002/jmri.22383. View