Constrast-enhanced Computed Tomography Radiomics Predicts CD27 Expression and Clinical Prognosis in Head and Neck Squamous Cell Carcinoma

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2022 Dec 2

PMID 36458007

Authors

Fang Wang

Wenhao Zhang

Ying Chai

Hanshao Wang

Zhonglong Liu

Yue He

Affiliations

Soon will be listed here.

Abstract

Objective: This study aimed to construct a radiomics model that predicts the expression level of in patients with head and neck squamous cell carcinoma (HNSCC).

Materials And Methods: Genomic data and contrast-enhanced computed tomography (CT) images of patients with HNSCC were downloaded from the Cancer Genome Atlas and Cancer Imaging Archive for prognosis analysis, image feature extraction, and model construction. We explored the potential molecular mechanisms underlying expression and its relationship with the immune microenvironment and predicted mRNA expression in HNSCC tissues. Using non-invasive, CT-based radiomics technology, we generated a radiomics model and evaluated its correlation with the related genes and HNSCC prognosis.

Results And Conclusion: The expression level of in HNSCC may significantly influence the prognosis of patients with HNSCC. Radiomics based on contrast-enhanced CT is potentially effective in predicting the expression level of .

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