Neuropathophysiology of Brain Injury

Overview

Journal Anesthesiol Clin

Specialty Anesthesiology

Date 2016 Aug 14

PMID 27521191

Citations 63

Authors

Nidia Quillinan

Paco S Herson

Richard J Traystman

Affiliations

Soon will be listed here.

Abstract

Every year in the United States, millions of individuals incur ischemic brain injury from stroke, cardiac arrest, or traumatic brain injury. These acquired brain injuries can lead to death or long-term neurologic and neuropsychological impairments. The mechanisms of ischemic and traumatic brain injury that lead to these deficiencies result from a complex interplay of interdependent molecular pathways, including excitotoxicity, acidotoxicity, ionic imbalance, oxidative stress, inflammation, and apoptosis. This article reviews several mechanisms of brain injury and discusses recent developments. Although much is known from animal models of injury, it has been difficult to translate these effects to humans.

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