Research Advances in Neuroblast Migration in Traumatic Brain Injury

Overview

Journal Mol Neurobiol

Specialties Molecular Biology
Neurology

Date 2024 Mar 20

PMID 38507029

Authors

Na Wu

Wenlang Li

Qiang Chen

Meng Chen

Siyuan Chen

Chongjie Cheng

Yimin Xie

Affiliations

Soon will be listed here.

Abstract

Neuroblasts were first derived from the adult mammalian brains in the 1990s by Reynolds et al. Since then, persistent neurogenesis in the subgranular zone (SGZ) of the hippocampus and subventricular zone (SVZ) has gradually been recognized. To date, reviews on neuroblast migration have largely investigated glial cells and molecular signaling mechanisms, while the relationship between vasculature and cell migration remains a mystery. Thus, this paper underlines the partial biological features of neuroblast migration and unravels the significance and mechanisms of the vasculature in the process to further clarify theoretically the neural repair mechanism after brain injury. Neuroblast migration presents three modes according to the characteristics of cells that act as scaffolds during the migration process: gliophilic migration, neurophilic migration, and vasophilic migration. Many signaling molecules, including brain-derived neurotrophic factor (BDNF), stromal cell-derived factor 1 (SDF-1), vascular endothelial growth factor (VEGF), and angiopoietin-1 (Ang-1), affect vasophilic migration, synergistically regulating the migration of neuroblasts to target areas along blood vessels. However, the precise role of blood vessels in the migration of neuroblasts needs to be further explored. The in-depth study of neuroblast migration will most probably provide theoretical basis and breakthrough for the clinical treatment of brain injury diseases.

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References

Quillinan N, Herson P, Traystman R . Neuropathophysiology of Brain Injury. Anesthesiol Clin. 2016; 34(3):453-64. PMC: 5214884. DOI: 10.1016/j.anclin.2016.04.011. View

Boldrini M, Fulmore C, Tartt A, Simeon L, Pavlova I, Poposka V . Human Hippocampal Neurogenesis Persists throughout Aging. Cell Stem Cell. 2018; 22(4):589-599.e5. PMC: 5957089. DOI: 10.1016/j.stem.2018.03.015. View

Peretto P, Giachino C, Aimar P, Fasolo A, Bonfanti L . Chain formation and glial tube assembly in the shift from neonatal to adult subventricular zone of the rodent forebrain. J Comp Neurol. 2005; 487(4):407-27. DOI: 10.1002/cne.20576. View

Bagnard D, Vaillant C, Khuth S, Dufay N, Lohrum M, Puschel A . Semaphorin 3A-vascular endothelial growth factor-165 balance mediates migration and apoptosis of neural progenitor cells by the recruitment of shared receptor. J Neurosci. 2001; 21(10):3332-41. PMC: 6762465. View

Saghatelyan A . Role of blood vessels in the neuronal migration. Semin Cell Dev Biol. 2009; 20(6):744-50. DOI: 10.1016/j.semcdb.2009.04.006. View

Grade S, Weng Y, Snapyan M, Kriz J, Malva J, Saghatelyan A . Brain-derived neurotrophic factor promotes vasculature-associated migration of neuronal precursors toward the ischemic striatum. PLoS One. 2013; 8(1):e55039. PMC: 3558494. DOI: 10.1371/journal.pone.0055039. View

Dillen Y, Kemps H, Gervois P, Wolfs E, Bronckaers A . Adult Neurogenesis in the Subventricular Zone and Its Regulation After Ischemic Stroke: Implications for Therapeutic Approaches. Transl Stroke Res. 2019; 11(1):60-79. DOI: 10.1007/s12975-019-00717-8. View

Muncie J, Weaver V . The Physical and Biochemical Properties of the Extracellular Matrix Regulate Cell Fate. Curr Top Dev Biol. 2018; 130:1-37. PMC: 6586474. DOI: 10.1016/bs.ctdb.2018.02.002. View

Kokovay E, Goderie S, Wang Y, Lotz S, Lin G, Sun Y . Adult SVZ lineage cells home to and leave the vascular niche via differential responses to SDF1/CXCR4 signaling. Cell Stem Cell. 2010; 7(2):163-73. PMC: 2916873. DOI: 10.1016/j.stem.2010.05.019. View

10.

Ono K, Tomasiewicz H, Magnuson T, Rutishauser U . N-CAM mutation inhibits tangential neuronal migration and is phenocopied by enzymatic removal of polysialic acid. Neuron. 1994; 13(3):595-609. DOI: 10.1016/0896-6273(94)90028-0. View

11.

Theisen U, Ernst A, Heyne R, Ring T, Thorn-Seshold O, Koster R . Microtubules and motor proteins support zebrafish neuronal migration by directing cargo. J Cell Biol. 2020; 219(10). PMC: 7659711. DOI: 10.1083/jcb.201908040. View

12.

Ngwenya L, Danzer S . Impact of Traumatic Brain Injury on Neurogenesis. Front Neurosci. 2019; 12:1014. PMC: 6333744. DOI: 10.3389/fnins.2018.01014. View

13.

Akter M, Kaneko N, Sawamoto K . Neurogenesis and neuronal migration in the postnatal ventricular-subventricular zone: Similarities and dissimilarities between rodents and primates. Neurosci Res. 2020; 167:64-69. DOI: 10.1016/j.neures.2020.06.001. View

14.

Sawada M, Matsumoto M, Sawamoto K . Vascular regulation of adult neurogenesis under physiological and pathological conditions. Front Neurosci. 2014; 8:53. PMC: 3955849. DOI: 10.3389/fnins.2014.00053. View

15.

Sun Y, Jin K, Xie L, Childs J, Mao X, Logvinova A . VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia. J Clin Invest. 2003; 111(12):1843-51. PMC: 161428. DOI: 10.1172/JCI17977. View

16.

Carabalona A, Hu D, Vallee R . KIF1A inhibition immortalizes brain stem cells but blocks BDNF-mediated neuronal migration. Nat Neurosci. 2016; 19(2):253-62. PMC: 4731285. DOI: 10.1038/nn.4213. View

17.

Edmondson J, Hatten M . Glial-guided granule neuron migration in vitro: a high-resolution time-lapse video microscopic study. J Neurosci. 1987; 7(6):1928-34. PMC: 6568879. View

18.

Bao M, Xie J, Huck W . Recent Advances in Engineering the Stem Cell Microniche in 3D. Adv Sci (Weinh). 2018; 5(8):1800448. PMC: 6096985. DOI: 10.1002/advs.201800448. View

19.

Noctor S, Flint A, Weissman T, Dammerman R, Kriegstein A . Neurons derived from radial glial cells establish radial units in neocortex. Nature. 2001; 409(6821):714-20. DOI: 10.1038/35055553. View

20.

Fujioka T, Kaneko N, Sawamoto K . Blood vessels as a scaffold for neuronal migration. Neurochem Int. 2019; 126:69-73. DOI: 10.1016/j.neuint.2019.03.001. View