Structure, Chemical Synthesis, and Biosynthesis of Prodiginine Natural Products

Overview

Journal Chem Rev

Publisher American Chemical Society

Specialty Chemistry

Date 2016 Jun 18

PMID 27314508

Citations 44

Authors

Dennis X Hu

David M Withall

Gregory L Challis

Regan J Thomson

Affiliations

Soon will be listed here.

Abstract

The prodiginine family of bacterial alkaloids is a diverse set of heterocyclic natural products that have likely been known to man since antiquity. In more recent times, these alkaloids have been discovered to span a wide range of chemical structures that possess a number of interesting biological activities. This review provides a comprehensive overview of research undertaken toward the isolation and structural elucidation of the prodiginine family of natural products. Additionally, research toward chemical synthesis of the prodiginine alkaloids over the last several decades is extensively reviewed. Finally, the current, evidence-based understanding of the various biosynthetic pathways employed by bacteria to produce prodiginine alkaloids is summarized.

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