Gregory L Challis
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Explore the profile of Gregory L Challis including associated specialties, affiliations and a list of published articles.
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120
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4805
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Recent Articles
1.
Fage C, Passmore M, Tatman B, Smith H, Jian X, Dissanayake U, et al.
JACS Au
. 2025 Jan;
5(1):144-157.
PMID: 39886563
Polyketide synthases (PKSs) are multidomain enzymatic assembly lines that biosynthesize a wide selection of bioactive natural products from simple building blocks. In contrast to their -acyltransferase (AT) counterparts, -AT PKSs...
2.
Woodgate J, Sumang F, Salliss M, Belousoff M, Ward A, Challis G, et al.
ACS Infect Dis
. 2024 Dec;
11(1):155-163.
PMID: 39651842
Persiathiacin A is a novel thiopeptide antibiotic produced by species UTMC 2448. It has potent activity against methicillin-resistant (MRSA) and . Thiopeptides, including persiathiacin A, exhibit antibacterial activity by inhibiting...
3.
Simm C, Lee T, Weerasinghe H, Walsh D, Nakou I, Shankar M, et al.
mBio
. 2024 Oct;
15(11):e0261124.
PMID: 39422464
Importance: Amphotericin B (AmpB) is one of the oldest antifungal drugs in clinical use. It is an effective therapeutic, but it comes with toxicity issues due to the similarities between...
4.
Dashti Y, Mohammadipanah F, Zhang Y, Cerqueira Diaz P, Vocat A, Zabala D, et al.
ACS Infect Dis
. 2024 Aug;
10(9):3378-3391.
PMID: 39189814
Thiopeptides are ribosomally biosynthesized and post-translationally modified peptides (RiPPs) that potently inhibit the growth of Gram-positive bacteria by targeting multiple steps in protein biosynthesis. The poor pharmacological properties of thiopeptides,...
5.
Wang K, Liu N, Liu M, Zhao P, Zhong N, Challis G, et al.
J Agric Food Chem
. 2024 Jun;
72(26):14760-14768.
PMID: 38899439
Potato common scab (PCS) is a widespread plant disease that lacks effective control measures. Using a small molecule elicitor, we activate the production of a novel class of polyketide antibiotics,...
6.
Baines C, Sargeant J, Fage C, Pugh H, Alkhalaf L, Challis G, et al.
J Am Soc Mass Spectrom
. 2024 Jun;
35(7):1490-1496.
PMID: 38830009
Collision-induced unfolding (CIU) of protein ions, monitored by ion mobility-mass spectrometry, can be used to assess the stability of their compact gas-phase fold and hence provide structural information. The bacterial...
7.
Jian X, Pang F, Hobson C, Jenner M, Alkhalaf L, Challis G
J Am Chem Soc
. 2024 Feb;
146(9):6114-6124.
PMID: 38389455
Microorganisms are remarkable chemists capable of assembling complex molecular architectures that penetrate cells and bind biomolecular targets with exquisite selectivity. Consequently, microbial natural products have wide-ranging applications in medicine and...
8.
Messenger S, McGuinniety E, Stevenson L, Owen J, Challis G, Ackerley D, et al.
Nat Chem Biol
. 2023 Nov;
20(2):251-260.
PMID: 37996631
The modular nature of nonribosomal peptide biosynthesis has driven efforts to generate peptide analogs by substituting amino acid-specifying domains within nonribosomal peptide synthetase (NRPS) enzymes. Rational NRPS engineering has increasingly...
9.
Fage C, Passmore M, Tatman B, Smith H, Jian X, Dissanayake U, et al.
bioRxiv
. 2023 Aug;
PMID: 37609184
Polyketide synthases (PKSs) are multi-domain enzymatic assembly lines that biosynthesise a wide selection of bioactive natural products from simple building blocks. In contrast to their -acyltransferase (AT) counterparts, -AT PKSs...
10.
Huang C, Zabala D, De Los Santos E, Song L, Corre C, Alkhalaf L, et al.
Nucleic Acids Res
. 2023 Jan;
51(3):1488-1499.
PMID: 36718812
Advances in DNA sequencing technology and bioinformatics have revealed the enormous potential of microbes to produce structurally complex specialized metabolites with diverse uses in medicine and agriculture. However, these molecules...