Prodigiosin: Unveiling the Crimson Wonder - a Comprehensive Journey from Diverse Bioactivity to Synthesis and Yield Enhancement

Overview

Journal Front Microbiol

Specialty Microbiology

Date 2024 Jun 21

PMID 38903802

Authors

Yonglin Lu

Derun Liu

Renhui Jiang

Ziyun Li

Xueyan Gao

Affiliations

Soon will be listed here.

Abstract

Prodigiosin (PG) is a red tripyrrole pigment from the prodiginine family that has attracted widespread attention due to its excellent biological activities, including anticancer, antibacterial and anti-algal activities. The synthesis and production of PG is of particular significance, as it has the potential to be utilized in a number of applications, including those pertaining to clinical drug development, food safety, and environmental management. This paper provides a systematic review of recent research on PG, covering aspects like chemical structure, bioactivity, biosynthesis, gene composition and regulation, and optimization of production conditions, with a particular focus on the biosynthesis and regulation of PG in Serratia marcescens. This provides a solid theoretical basis for the drug development and production of PG, and is expected to promote the further development of PG in medicine and other applications.

Citing Articles

Characterization of Serratia marcescens (OK482790)' prodigiosin along with in vitro and in silico validation for its medicinal bioactivities.

Hamada M, Mohamed E BMC Microbiol. 2024; 24(1):495.

PMID: 39587466 PMC: 11587630. DOI: 10.1186/s12866-024-03634-5.

Relationships of Prodiginins Mechanisms and Molecular Structures to their Antiproliferative Effects.

Ayoub E, Azoubi Z, Nadia Z, Assia M, Mohammed M Anticancer Agents Med Chem. 2024; 24(19):1383-1395.

PMID: 39113301 DOI: 10.2174/0118715206314212240805105735.

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