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2D Representation of Transcriptomes by T-SNE Exposes Relatedness Between Human Tissues

Overview
Journal PLoS One
Specialties General Medicine
Science
Date 2016 Feb 25
PMID 26906061
Citations 22
Authors
Erdogan Taskesen
Marcel J T Reinders
Affiliations
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Abstract

The GTEx Consortium reported that hierarchical clustering of RNA profiles from 25 unique tissue types among 1641 individuals accurately distinguished the tissue types, but a multidimensional scaling failed to generate a 2D projection of the data that separates tissue-subtypes. In this study we show that a projection by t-Distributed Stochastic Neighbor Embedding is in line with the cluster analysis which allows a more detailed examination and visualization of human tissue relationships.

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