The Semantic Network at Work and Rest: Differential Connectivity of Anterior Temporal Lobe Subregions

Overview

Journal J Neurosci

Specialty Neurology

Date 2016 Feb 5

PMID 26843633

Citations 104

Authors

Rebecca L Jackson

Paul Hoffman

Gorana Pobric

Matthew A Lambon Ralph

Affiliations

Soon will be listed here.

Abstract

Significance Statement: Previous studies have shown that semantic cognition depends on subregions of the anterior temporal lobe (ATL). However, the network of regions functionally connected to these subregions has not been demarcated. Here, we show that these ventrolateral anterior temporal subregions form part of a network responsible for semantic processing during both rest and an explicit semantic task. This demonstrates the existence of a core functional network responsible for multimodal semantic cognition regardless of state. Distinct connectivity is identified in the superior ATL, which is connected to auditory and language areas. Understanding the functional connectivity of semantic cognition allows greater understanding of how this complex process may be performed and the role of distinct subregions of the anterior temporal cortex.

Citing Articles

Semantic Integration Demands Modulate Large-Scale Network Interactions in the Brain.

Nieberlein L, Martin S, Williams K, Gussew A, Cyriaks S, Scheer M Hum Brain Mapp. 2024; 45(18):e70113.

PMID: 39723465 PMC: 11669845. DOI: 10.1002/hbm.70113.

The Dimensionality of Neural Coding for Cognitive Control Is Gradually Transformed within the Lateral Prefrontal Cortex.

Chiou R, Duncan J, Jefferies E, Lambon Ralph M J Neurosci. 2024; 45(6).

PMID: 39663116 PMC: 11800757. DOI: 10.1523/JNEUROSCI.0233-24.2024.

The "limbic network," comprising orbitofrontal and anterior temporal cortex, is part of an extended default network: Evidence from multi-echo fMRI.

Girn M, Setton R, Turner G, Nathan Spreng R Netw Neurosci. 2024; 8(3):860-882.

PMID: 39355434 PMC: 11398723. DOI: 10.1162/netn_a_00385.

Perplexity of utterances in untreated first-episode psychosis: an ultra-high field MRI dynamic causal modelling study of the semantic network.

Alonso-Sanchez M, Hinzen W, He R, Gati J, Palaniyappan L J Psychiatry Neurosci. 2024; 49(4):E252-E262.

PMID: 39122409 PMC: 11318974. DOI: 10.1503/jpn.240031.

Aberrant brain language network in schizophrenia spectrum disorder: a systematic review of its relation to language signs beyond symptoms.

Alonso-Sanchez M, Z-Rivera L, Otero M, Portal J, Cavieres A, Alfaro-Faccio P Front Psychiatry. 2024; 15:1244694.

PMID: 39026525 PMC: 11254709. DOI: 10.3389/fpsyt.2024.1244694.

References

Nathan Spreng R, Stevens W, Chamberlain J, Gilmore A, Schacter D . Default network activity, coupled with the frontoparietal control network, supports goal-directed cognition. Neuroimage. 2010; 53(1):303-17. PMC: 2914129. DOI: 10.1016/j.neuroimage.2010.06.016. View

Shimotake A, Matsumoto R, Ueno T, Kunieda T, Saito S, Hoffman P . Direct Exploration of the Role of the Ventral Anterior Temporal Lobe in Semantic Memory: Cortical Stimulation and Local Field Potential Evidence From Subdural Grid Electrodes. Cereb Cortex. 2014; 25(10):3802-17. PMC: 4585516. DOI: 10.1093/cercor/bhu262. View

Noonan K, Jefferies E, Corbett F, Lambon Ralph M . Elucidating the nature of deregulated semantic cognition in semantic aphasia: evidence for the roles of prefrontal and temporo-parietal cortices. J Cogn Neurosci. 2009; 22(7):1597-613. DOI: 10.1162/jocn.2009.21289. View

McIntosh A . Mapping cognition to the brain through neural interactions. Memory. 2000; 7(5-6):523-48. DOI: 10.1080/096582199387733. View

Berker E, Berker A, Smith A . Translation of Broca's 1865 report. Localization of speech in the third left frontal convolution. Arch Neurol. 1986; 43(10):1065-72. DOI: 10.1001/archneur.1986.00520100069017. View

Embleton K, Haroon H, Morris D, Lambon Ralph M, Parker G . Distortion correction for diffusion-weighted MRI tractography and fMRI in the temporal lobes. Hum Brain Mapp. 2010; 31(10):1570-87. PMC: 6870737. DOI: 10.1002/hbm.20959. View

Spitsyna G, Warren J, Scott S, Turkheimer F, Wise R . Converging language streams in the human temporal lobe. J Neurosci. 2006; 26(28):7328-36. PMC: 6674192. DOI: 10.1523/JNEUROSCI.0559-06.2006. View

Luders H, Lesser R, Hahn J, Dinner D, MORRIS H, Wyllie E . Basal temporal language area. Brain. 1991; 114 ( Pt 2):743-54. DOI: 10.1093/brain/114.2.743. View

Hickok G, Poeppel D . Dorsal and ventral streams: a framework for understanding aspects of the functional anatomy of language. Cognition. 2004; 92(1-2):67-99. DOI: 10.1016/j.cognition.2003.10.011. View

10.

OReilly J, Woolrich M, Behrens T, Smith S, Johansen-Berg H . Tools of the trade: psychophysiological interactions and functional connectivity. Soc Cogn Affect Neurosci. 2012; 7(5):604-9. PMC: 3375893. DOI: 10.1093/scan/nss055. View

11.

Murphy K, Bodurka J, Bandettini P . How long to scan? The relationship between fMRI temporal signal to noise ratio and necessary scan duration. Neuroimage. 2006; 34(2):565-74. PMC: 2223273. DOI: 10.1016/j.neuroimage.2006.09.032. View

12.

Pascual B, Masdeu J, Hollenbeck M, Makris N, Insausti R, Ding S . Large-scale brain networks of the human left temporal pole: a functional connectivity MRI study. Cereb Cortex. 2013; 25(3):680-702. PMC: 4318532. DOI: 10.1093/cercor/bht260. View

13.

Mesulam M . Large-scale neurocognitive networks and distributed processing for attention, language, and memory. Ann Neurol. 1990; 28(5):597-613. DOI: 10.1002/ana.410280502. View

14.

Ding S, Van Hoesen G, Cassell M, Poremba A . Parcellation of human temporal polar cortex: a combined analysis of multiple cytoarchitectonic, chemoarchitectonic, and pathological markers. J Comp Neurol. 2009; 514(6):595-623. PMC: 3665344. DOI: 10.1002/cne.22053. View

15.

Catani M, Ffytche D . The rises and falls of disconnection syndromes. Brain. 2005; 128(Pt 10):2224-39. DOI: 10.1093/brain/awh622. View

16.

Fornito A, Harrison B, Zalesky A, Simons J . Competitive and cooperative dynamics of large-scale brain functional networks supporting recollection. Proc Natl Acad Sci U S A. 2012; 109(31):12788-93. PMC: 3412011. DOI: 10.1073/pnas.1204185109. View

17.

Moran M, Mufson E, Mesulam M . Neural inputs into the temporopolar cortex of the rhesus monkey. J Comp Neurol. 1987; 256(1):88-103. DOI: 10.1002/cne.902560108. View

18.

Humphreys G, Lambon Ralph M . Fusion and Fission of Cognitive Functions in the Human Parietal Cortex. Cereb Cortex. 2014; 25(10):3547-60. PMC: 4585503. DOI: 10.1093/cercor/bhu198. View

19.

Binder J, Frost J, Hammeke T, Bellgowan P, Rao S, Cox R . Conceptual processing during the conscious resting state. A functional MRI study. J Cogn Neurosci. 1999; 11(1):80-95. DOI: 10.1162/089892999563265. View

20.

Dehaene S, Piazza M, Pinel P, Cohen L . Three parietal circuits for number processing. Cogn Neuropsychol. 2010; 20(3):487-506. DOI: 10.1080/02643290244000239. View