Aberrant Brain Language Network in Schizophrenia Spectrum Disorder: a Systematic Review of Its Relation to Language Signs Beyond Symptoms

Overview

Journal Front Psychiatry

Specialty Psychiatry

Date 2024 Jul 19

PMID 39026525

Authors

Maria F Alonso-Sanchez

Lucia Z-Rivera

Monica Otero

Jorge Portal

Alvaro Cavieres

Pedro Alfaro-Faccio

Affiliations

Soon will be listed here.

Abstract

Background: Language disturbances are a core feature of schizophrenia, often studied as a formal thought disorder. The neurobiology of language in schizophrenia has been addressed within the same framework, that language and thought are equivalents considering symptoms and not signs. This review aims to systematically examine published peer-reviewed studies that employed neuroimaging techniques to investigate aberrant brain-language networks in individuals with schizophrenia in relation to linguistic signs.

Methods: We employed a language model for automatic data extraction. We selected our studies according to the PRISMA recommendations, and we conducted the quality assessment of the selected studies according to the STROBE guidance.

Results: We analyzed the findings from 37 studies, categorizing them based on patient characteristics, brain measures, and language task types. The inferior frontal gyrus (IFG) and superior temporal gyrus (STG) exhibited the most significant differences among these studies and paradigms.

Conclusions: We propose guidelines for future research in this field based on our analysis. It is crucial to investigate larger networks involved in language processing, and language models with brain metrics must be integrated to enhance our understanding of the relationship between language and brain abnormalities in schizophrenia.

References

Andreasen N . Thought, language, and communication disorders. I. Clinical assessment, definition of terms, and evaluation of their reliability. Arch Gen Psychiatry. 1979; 36(12):1315-21. DOI: 10.1001/archpsyc.1979.01780120045006. View

Wroblewski A, He Y, Straube B . Dynamic Causal Modelling suggests impaired effective connectivity in patients with schizophrenia spectrum disorders during gesture-speech integration. Schizophr Res. 2019; 216:175-183. DOI: 10.1016/j.schres.2019.12.005. View

Holper L, Aleksandrowicz A, Muller M, Ajdacic-Gross V, Haker H, Fallgatter A . Brain correlates of verbal fluency in subthreshold psychosis assessed by functional near-infrared spectroscopy. Schizophr Res. 2015; 168(1-2):23-9. DOI: 10.1016/j.schres.2015.07.043. View

Bleich-Cohen M, Hendler T, Kotler M, Strous R . Reduced language lateralization in first-episode schizophrenia: an fMRI index of functional asymmetry. Psychiatry Res. 2009; 171(2):82-93. DOI: 10.1016/j.pscychresns.2008.03.002. View

Glasser M, Coalson T, Robinson E, Hacker C, Harwell J, Yacoub E . A multi-modal parcellation of human cerebral cortex. Nature. 2016; 536(7615):171-178. PMC: 4990127. DOI: 10.1038/nature18933. View

Wensing T, Cieslik E, Muller V, Hoffstaedter F, Eickhoff S, Nickl-Jockschat T . Neural correlates of formal thought disorder: An activation likelihood estimation meta-analysis. Hum Brain Mapp. 2017; 38(10):4946-4965. PMC: 5685170. DOI: 10.1002/hbm.23706. View

Kircher T, Whitney C, Krings T, Huber W, Weis S . Hippocampal dysfunction during free word association in male patients with schizophrenia. Schizophr Res. 2008; 101(1-3):242-55. DOI: 10.1016/j.schres.2008.02.003. View

Zhang L, Vander Meer L, Opmeer E, Marsman J, Ruhe H, Aleman A . Altered functional connectivity during self- and close other-reflection in patients with bipolar disorder with past psychosis and patients with schizophrenia. Neuropsychologia. 2016; 93(Pt A):97-105. DOI: 10.1016/j.neuropsychologia.2016.09.020. View

Destrieux C, Fischl B, Dale A, Halgren E . Automatic parcellation of human cortical gyri and sulci using standard anatomical nomenclature. Neuroimage. 2010; 53(1):1-15. PMC: 2937159. DOI: 10.1016/j.neuroimage.2010.06.010. View

10.

Royer C, Delcroix N, Leroux E, Alary M, Razafimandimby A, Brazo P . Functional and structural brain asymmetries in patients with schizophrenia and bipolar disorders. Schizophr Res. 2014; 161(2-3):210-4. DOI: 10.1016/j.schres.2014.11.014. View

11.

Moher D, Liberati A, Tetzlaff J, Altman D . Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med. 2009; 151(4):264-9, W64. DOI: 10.7326/0003-4819-151-4-200908180-00135. View

12.

Cock P, Antao T, Chang J, Chapman B, Cox C, Dalke A . Biopython: freely available Python tools for computational molecular biology and bioinformatics. Bioinformatics. 2009; 25(11):1422-3. PMC: 2682512. DOI: 10.1093/bioinformatics/btp163. View

13.

Wasserthal J, Neher P, Maier-Hein K . TractSeg - Fast and accurate white matter tract segmentation. Neuroimage. 2018; 183:239-253. DOI: 10.1016/j.neuroimage.2018.07.070. View

14.

Tagamets M, Cortes C, Griego J, Elvevag B . Neural correlates of the relationship between discourse coherence and sensory monitoring in schizophrenia. Cortex. 2013; 55:77-87. PMC: 3899100. DOI: 10.1016/j.cortex.2013.06.011. View

15.

Surbeck W, Hanggi J, Scholtes F, Viher P, Schmidt A, Stegmayer K . Anatomical integrity within the inferior fronto-occipital fasciculus and semantic processing deficits in schizophrenia spectrum disorders. Schizophr Res. 2020; 218:267-275. DOI: 10.1016/j.schres.2019.12.025. View

16.

Rannikko I, Paavola L, Haapea M, Huhtaniska S, Miettunen J, Veijola J . Verbal learning and memory and their associations with brain morphology and illness course in schizophrenia spectrum psychoses. J Clin Exp Neuropsychol. 2012; 34(7):698-713. DOI: 10.1080/13803395.2012.668875. View

17.

Ragland J, Moelter S, Bhati M, Valdez J, Kohler C, Siegel S . Effect of retrieval effort and switching demand on fMRI activation during semantic word generation in schizophrenia. Schizophr Res. 2007; 99(1-3):312-23. PMC: 2383319. DOI: 10.1016/j.schres.2007.11.017. View

18.

Han S, Nestor P, Hale-Spencer M, Cohen A, Niznikiewicz M, McCarley R . Functional neuroimaging of word priming in males with chronic schizophrenia. Neuroimage. 2007; 35(1):273-82. PMC: 1852450. DOI: 10.1016/j.neuroimage.2006.11.029. View

19.

BORJESON A, Nylander I . A case of severe developmental motor aphasia with psychotic symptoms successfully treated by speech therapy. Acta Paedopsychiatr. 1963; 30:59-70. View

20.

van Veelen N, Vink M, Ramsey N, Sommer I, van Buuren M, Hoogendam J . Reduced language lateralization in first-episode medication-naive schizophrenia. Schizophr Res. 2011; 127(1-3):195-201. DOI: 10.1016/j.schres.2010.12.013. View