Live Births Resulting from 0PN-derived Embryos in Conventional IVF Cycles

Overview

Journal J Assist Reprod Genet

Publisher Springer

Specialties Genetics
Reproductive Medicine

Date 2016 Jan 11

PMID 26749389

Citations 12

Authors

Jing Liu

Xing Ling Wang

Xiao Zhang

Chun Yan Shen

Zhan Zhang

Affiliations

Soon will be listed here.

Abstract

Purpose: The aim of this study was to (1) investigate the incidence of embryos derived from "unfertilized oocytes" i.e., oocytes not displaying pronuclei (0PN) at the time of the fertilization check and (2) determine the clinical pregnancy rates when transferring 0PN-derived embryos.

Methods: In this retrospective study, 4424 IVF-ET cycles were reviewed.

Results: In total, 11.3% (4966/43,949) 0PN-derived embryos were observed. It was found that female age, number of oocytes, and the top-quality embryo rate were significantly correlated with 0PN-derived embryo occurrence. The source of embryos transferred did not impact significantly on clinical pregnancy and live-birth rates. Of the 183 cycles included in this study where 275 0PN-derived embryos were transferred in total, only 0PN-derived embryos were available in 70 of those cycles. It was noteworthy that 13 healthy infants resulted from 0PN-derived embryos with an implantation rate of 17.0%.

Conclusion: These results indicate that the traditional method of excluding embryos because of those oocytes originally lacking any sign of a pronucleus at the fertilization check should be re-considered as transferring 0PN-derived embryos with subsequent expected developmental performance may be considered as an option for those patients where no other embryos are available.

Citing Articles

Developmental potential of zygotes without pronucleus (0PN) and pregnancy outcomes after single euploid blastocyst transfers.

Moon J, Zhang J, Yu B J Assist Reprod Genet. 2025; .

PMID: 39984800 DOI: 10.1007/s10815-025-03430-8.

Use of time-lapse technology on fertilization verification, embryo evaluation, and utilization: A national survey in Japan.

Yamada M, Ezoe K, Ueno S, Yoshino O, Takahashi T AJOG Glob Rep. 2024; 4(4):100397.

PMID: 39493437 PMC: 11530904. DOI: 10.1016/j.xagr.2024.100397.

Developmental perturbation in human embryos: Clinical and biological significance learned from time-lapse images.

Ezoe K, Takahashi T, Miki T, Kato K Reprod Med Biol. 2024; 23(1):e12593.

PMID: 38983691 PMC: 11232294. DOI: 10.1002/rmb2.12593.

Developmental potential of non- and mono-pronuclear zygotes and associated clinical outcomes in IVF cycles.

Zhu M, Dong Q, Zhu Y, Le Y, Wang T, Zhou Y Front Endocrinol (Lausanne). 2024; 15:1361734.

PMID: 38532894 PMC: 10964251. DOI: 10.3389/fendo.2024.1361734.

Clinical outcomes of frozen-thawed blastocysts from zygotes with no or one pronucleus for in vitro fertilization and intracytoplasmic sperm injection cycles.

Tong X, Jin J, Xue Y, Fang L, Zhu H, Jiang L Arch Gynecol Obstet. 2023; 308(3):1015-1022.

PMID: 37391645 PMC: 10348965. DOI: 10.1007/s00404-023-07118-1.

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